NCT06778226Completed
ThRombectomy In Mild Ischemic Stroke With a Visible Intracranial veSsel Occlusion
Source: ClinicalTrials.gov · Last updated 11 May 2026
Brief summary (registry, in English)
The purpose of TRIMIS is to study how a medical procedure by the name of endovascular therapy compares to medical treatment alone in patients with mild stroke and a blood vessel occlusion in the brain
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 4827 (actual)
- First submitted
- 10 Jan 2025
- Start date
- 1 Jan 2018
- Primary completion date
- 22 Apr 2026
- Lead sponsor
- University of Miami
- Diseases
- Stroke
- NCT number
- NCT06778226
What you commit to
- Study type: Observational
- Participants enrolled: 4827
- From 1 Jan 2018 to the primary completion date, 22 Apr 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Stroke symptoms due to another non-ischemic acute neurological condition such as seizure with Post-ictal Todd's paralysis or focal neurological signs due to severe hypo- or hyperglycemia.
- Hyperdensity on Non-contrast Computed Tomography consistent with intracranial hemorrhage. Any clinical suspicion of any intracranial hemorrhage even in the absence of visible blood on baseline brain imaging.
- Large acute stroke \>1/3 Middle Cerebral Artery territory or Alberta Stroke Programme Early CT score (ASPECTS\<6 or established frank hypodensity relevant to the presenting acute stroke already visible on baseline CT scan.
- Patient has a severe or fatal or disabling illness that will impact decision regarding acute reperfusion therapies.
- Stroke occurred as an inpatient.
Other
- Findings on acute CT or MRI to suggest that the
- Pregnancy.
- Clinical history, past imaging and clinical judgment suggest that the intracranial occlusion is chronic.
- Inclusion into any randomized control trials.
Who the study is looking for
- Acute ischemic stroke in an adult patient (18 years of age or older).
- Onset (Last Seen Normal) time to treatment time \<24 hours or unknown Last Seen Normal in whom Endovascular Therapy could be considered per local radiographic guidelines.
- Mild stroke defined as an NIH Stroke Scale ≤ 5 at the time of treatment decision.
- Patients with NIH Stroke Scale=0 can be included in the study if they have relevant abnormalities on neurological exam.
- An acute intracranial vessel occlusion (Intracranial Internal Carotid Artery terminus (T or L clot), Middle Cerebral Artery (M1, M2, M3/beyond), Anterior Cerebral Artery (A1, A2, A3), V4, Basilar, Posterior Cerebral Artery) defined by non-invasive acute imaging (Computed Tomography, angiography (Computed Tomography Angiography) or Magnetic Resonance angiography (MRA)) that is neurologically relevant to the presenting symptoms and signs.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Boston Medical Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| University of Miami Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Brown University Coordinator of this site? Confirm its status | Providence | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.