NCT06779916Recruiting
Autophagy/Apoptosis Balance in Placental Vascular Pathologies
Study of the Autophagy/Apoptosis Balance in Placental Vascular Pathologies
Source: ClinicalTrials.gov · Last updated 6 May 2026
Brief summary (registry, in English)
Pregnancy increases the risk of thrombosis. Placenta-mediated diseases are a risk factor for cardiovascular pathologies and can lead to maternal-fetal morbidity and mortality. It is essential to understand the cellular and molecular mechanisms of dysfunctions at the vascular-placental interface so that systemic vascular risk can be characterized and, ultimately, screened for, on the basis of new markers (targeted preventive management). Deregulated autophagy could be the starting point for cell death by apoptosis or necrosis leading to complications. The pathophysiological mechanisms involved in trophoblast apoptosis are incompletely described. This project follows on from the GrossAuTop-1 study, which investigated the intra- and inter-individual variability of autophagy and apoptosis activities in women during pregnancy. The aim of this project is to study autophagy and apoptosis activities specifically in women developing a placental vascular complication during pregnancy.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 50 (estimated)
- First submitted
- 6 Jan 2025
- Start date
- 2 May 2025
- Primary completion date
- 1 May 2028
- Lead sponsor
- Centre Hospitalier Universitaire de Nīmes
- NCT number
- NCT06779916
What you commit to
- Study type: Observational
- Planned participants: 50
- From 2 May 2025 to the primary completion date, 1 May 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Presence of hypertension and/or proteinuria prior to pregnancy.
- Participant in an interventional drug study.
Other
- Multiple pregnancy.
- Persons in a period of exclusion determined by another study.
- Persons under court protection, guardianship or curatorship.
- Persons unable to give consent.
- Persons for whom it is impossible to give informed information.
Who the study is looking for
- Pregnant women developing a placental vascular complication (preeclampsia and/or intrauterine growth retardation), hospitalized and delivering at Nimes University Hospital.
- Pregnant woman with free and informed consent.
- Pregnant woman affiliated with and/or benefiting from a health insurance scheme.
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Nîmes University Hospital Coordinator of this site? Confirm its status | Nîmes | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.