NCT06780423Recruiting
Structural Characteristics of Trunk and Limb Muscles in Cachectic Colorectal Cancer Patients
Source: ClinicalTrials.gov · Last updated 9 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Until now, cancer is still associated with high morbidity and mortality, and is therefore a big issue for the public health. Colorectal cancer is the second leading cause of cancer death in developed countries. In advanced colorectal cancer, 60% of these patients develop cachexia. The presence of cachexia plays an important role in the high mortality rate of cancer. Cachexia is characterized by involuntary weight loss with loss of skeletal muscle with or without loss of fat mass. The aim of this study is to determine the feasibility of taking muscle biopsies of cachectic colorectal cancer patients. Skeletal muscle characteristics will be compared between biopsies of the m. erector spinae and the m. vastus lateralis from cachectic colorectal cancer patients, non-cachectic colorectal cancer patients and healthy controls. 10 cachectic, 25 non-cachectic, and 25 healthy controls will be recruited for this study. It is an observational study, so measurements will be taken at one time point. Interventions/measurements: * muscle biopsies * blood samples * 3D freehand ultrasound * Short physical performance battery test * handgrip strength * questionnaires (activity pattern, quality of life)
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 60 (estimated)
- First submitted
- 13 Jan 2025
- Start date
- 23 Jan 2022
- Primary completion date
- 15 Mar 2025
- Lead sponsor
- Hasselt University
- Diseases
- Colorectal cancer
- NCT number
- NCT06780423
What you commit to
- Study type: Observational
- Planned participants: 60
- From 23 Jan 2022 to the primary completion date, 15 Mar 2025
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Mental of psychological condition
- Muscle diseases affecting the spine and lower limbs
- Bedridden
- Non-Cachectic cancer patients.
- Mental of psychological condition
- Muscle diseases affecting the spine and lower limbs
- Mental of psychological condition
- Muscle diseases affecting the spine and lower limbs
Other
- Insufficient knowledge of the Dutch language
- Insufficient knowledge of the Dutch language
- Bedridden
- Healthy controls.
- Insufficient knowledge of the Dutch language
- Bedridden
Who the study is looking for
- minimum age of 18 years old
- unwanted weight loss \> 5% in the last 6 months OR \> 2% unwanted weight loss in combination with a BMI \< 20kg/m2 OR \>2% unwanted weight loss in combination with sarcopenia
- Cachexia staging score (CSS): 5-12
- minimum age of 18 years old
- No unwanted weight loss \> 5% in the last 6 months OR \> 2% unwanted weight loss in combination with a BMI \< 20kg/m2 OR \>2% unwanted weight loss in combination with sarcopenia
- Cachexia staging score (CSS): 0-2
- \- minimum age of 18 years old
Criteria the registry did not label
- Cachectic colorectal cancer patients.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hasselt University - REVAL research institution Coordinator of this site? Confirm its status | Diepenbeek | Belgium | Recruiting |
| Jessa Hospital Coordinator of this site? Confirm its status | Hasselt | Belgium | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.