NCT06784908Recruiting
Stress and Pain in People Living With HIV
Stress-immune Mechanisms for People Living With HIV, CUD and Depression
Source: ClinicalTrials.gov · Last updated 27 Apr 2026
Brief summary (registry, in English)
This is a basic human experimental study utilizing 4 groups of individuals with and without HIV and complex morbidities of cannabis use disorder and major depression who will participate in 2 sessions of the Yale Pain Stress Task (YPST) and follow-up phase to assess drug use and mood symptoms.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 16 Jan 2025
- Start date
- 16 Jan 2025
- Primary completion date
- 31 Jan 2030
- Lead sponsor
- Yale University
- Diseases
- HIV
- NCT number
- NCT06784908
What you commit to
- Study type: Interventional
- Planned participants: 120
- From 16 Jan 2025 to the primary completion date, 31 Jan 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- medications with known central effects on HPA axis and cytokines/immune function
Other illness
- current use or past history of cocaine or opioid use disorder
- history of any psychotic disorder
- current diagnoses of bipolar disorder and PTSD
- significant underlying medical conditions such as cerebral, renal, thyroid or cardiac pathology that would interfere with study participation
Other
- meet primary, current moderate and severe criteria for other SUD including cocaine, alcohol, opiates, sedatives, nicotine
- psychotic or otherwise severely psychiatrically disabled (i.e., suicidal, homicidal, current mania)
- women who are pregnant, nursing or those using hormonal birth control that affect HPA axis cortisol responses.
Who the study is looking for
- good health as verified by screening examination
- Able to read English and complete study evaluations and provide informed written and verbal consent. Additional criteria PLWH
- HIV-1 lab test positive
- undetectable viral load
- good ART adherence
- Additional criteria by group:
- PLWH +CM:
- CB positive urine toxicology
- meet DSM-5 criteria for CUD and MDD as assessed using SCID-I. HC
- HIV-1 test negative
- urine toxicology negative
- no major medical and psychiatric diagnoses based on DSM-V.
- PLWH Only:
- HIV-1 test positive
- urine toxicology negative
- no major medical and psychiatric diagnoses based on DSM-V.
- CM Only:
- HIV-1 test negative
- urine toxicology positive
- meet DSM-5 criteria for CUD and MDD as assessed using SCID-I
Age in the registry: 18 years to 68 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Yale Stress Center Coordinator of this site? Confirm its status | New Haven | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.