NCT06786195Completed
Bone Myoregulation Reflex in Senile Osteoporosis
Is the Bone Myoregulation Reflex Response to Weight-Bearing Activities Low in Senile Osteoporosis?
Source: ClinicalTrials.gov · Last updated 13 May 2025
Brief summary (registry, in English)
Osteoporosis is a systemic skeletal disease characterized by weakened and fragile bones. It often remains asymptomatic in its early stages but can lead to serious health problems, particularly fractures.The mechanostat theory explains that bone mass is regulated by mechanical loading. Increased activity stimulates bone formation, while decreased activity promotes bone resorption. The "bone reflex" concept further suggests that the nervous system plays a crucial role in this process by regulating both bone metabolism (osteoregulation) and muscle activity (myoregulation) in response to mechanical loading.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 22 (actual)
- First submitted
- 9 Jan 2025
- Start date
- 15 Feb 2025
- Primary completion date
- 15 Apr 2025
- Lead sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
- Diseases
- Osteoporosis
- NCT number
- NCT06786195
What you commit to
- Study type: Interventional
- Participants enrolled: 22
- From 15 Feb 2025 to the primary completion date, 15 Apr 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of musculoskeletal surgery within the past year
- Individuals with health conditions that severely affect mobility
- Vestibular disorders
- Other rheumatic, psychiatric, or severe neurological diseases
- Chronic decompensated cardiac, renal, or hepatic insufficiency
- History of fractures or prostheses in the lower extremities
- History of kidney stones
- History of malignancy
- History of osteomalacia or vitamin D deficiency
Other
- Visual impairments
- Panic attacks
- Individuals with skin lesions on the soleus muscle
- 2+ or more edema in the lower extremities, lymphedema
Who the study is looking for
- DXA T-scores ≤-2.5 (osteoporotic) or T-scores \> -1 (no bone loss)
- Individuals who agree to participate in the study
Age in the registry: 60 years to 70 years · Sex: Male · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Istanbul Physical Therapy Rehabilitation Training and Research Hospital Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.