NCT06787105Recruiting
Fruquintinib in Patients With Metastatic Colorectal Cancer
Fruquintinib in Patients With Metastatic Colorectal Cancer: A Prospective, Multicenter, Observational Study
Source: ClinicalTrials.gov · Last updated 4 Sept 2026
Brief summary (registry, in English)
FRUQUENT is an observational study in Germany. The goal of the study is to evaluate how well Fruquintinib works to treat patients with metastatic colorectal cancer that have previously been treated with available standard therapies. To this end, it will be analyzed how well patients respond to the therapy in the clinical routine. Further points of interest to the study are survival data, safety data, the use of medical care facilities, and the quality of life of patients treated with Fruquintinib. Participants will be treated as decided by the treating physician and according to their routine practice. FRUQUENT is accompanied by a translational research project combining real-world clinical data with foundational research to stratify patient collectives in regards to the therapeutic benefit of fruquintinib.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 150 (estimated)
- First submitted
- 16 Jan 2025
- Start date
- 17 Feb 2025
- Primary completion date
- Dec 2027
- Lead sponsor
- iOMEDICO AG
- Diseases
- Colorectal cancer
- NCT number
- NCT06787105
What you commit to
- Study type: Observational
- Planned participants: 150
- From 17 Feb 2025 to the primary completion date, Dec 2027
- 42 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participation in an interventional clinical trial (except follow-up) within 30 days prior to enrollment or start of treatment with fruquintinib, whatever comes first.
Other
- Contraindications according to current SmPC.
Who the study is looking for
- Aged 18 years or older.
- Indication and decision for therapy with fruquintinib in accordance with the current German SmPC of fruquintinib as monotherapy for patients with mCRC.
- Prior treatment with available standard therapies, including fluoropyrimidine-, oxaliplatin-, and irinotecan based chemotherapies, anti VEGF therapy, and if RAS wild-type, anti EGFR therapy.
- Progression on or intolerance to treatment with either trifluridine/tipiracil and/or regorafenib.
- Other criteria according to current SmPC.
- Signed written informed consent.\* \* Patients are allowed to be enrolled up to 6 weeks after their first dose of fruquintinib. These patients cannot participate in the PRO assessments.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (42)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| MVZ am Klinikum Aschaffenburg GmbH Coordinator of this site? Confirm its status | Aschaffenburg | Germany | Recruiting |
| Evangelisches Waldkrankenhaus Spandau Innere Medizin I Coordinator of this site? Confirm its status | Berlin | Germany | Recruiting |
| DRK Kliniken Berlin Köpenick Klinik für Allgemein-, Viszeral- & Minimalinvasive Chirurgie Coordinator of this site? Confirm its status | Berlin | Germany | Recruiting |
| Hämatologikum Biberach Coordinator of this site? Confirm its status | Biberach | Germany | Recruiting |
| MVZ für Hämatologie und Onkologie Köln Am Sachsenring GmbH Coordinator of this site? Confirm its status | Cologne | Germany | Recruiting |
| Ambulantes Zentrum für Hämatologie & Onkologie Coordinator of this site? Confirm its status | Cottbus | Germany | Recruiting |
| Gemeinschaftspraxis Dr. Mohm / Dr. Siklaky / Mann Coordinator of this site? Confirm its status | Dresden | Germany | Recruiting |
| Onkozentrum Dresden Coordinator of this site? Confirm its status | Dresden | Germany | Recruiting |
| BAG / Onkologische Gemeinschaftspraxis Coordinator of this site? Confirm its status | Dresden | Germany | Recruiting |
| Evang. Kliniken Essen-Mitte (KEM) Internistische Onkologie Coordinator of this site? Confirm its status | Essen | Germany | Recruiting |
| Praxis Internistischer Onkologie und Hämatologie (PIOH) Coordinator of this site? Confirm its status | Frechen | Germany | Recruiting |
| Praxis für interdisziplinäre Onkologie & Hämatologie Coordinator of this site? Confirm its status | Freiburg im Breisgau | Germany | Recruiting |
| Schwerpunktpraxis Hämatologie & Internistische Onkologie Coordinator of this site? Confirm its status | Fürth | Germany | Recruiting |
| ÜBAG Onkologische Kooperation Harz GbR Coordinator of this site? Confirm its status | Goslar | Germany | Recruiting |
| Hämatologisch Onkologische Praxis Eppendorf (HOPE) Coordinator of this site? Confirm its status | Hamburg | Germany | Recruiting |
| Überörtliche Gemeinschaftspraxis Schwerpunkt Haematologie, internist Onkologie & Palliativmedizin Coordinator of this site? Confirm its status | Hamburg | Germany | Recruiting |
| Gemeinschaftspraxis Dr. Haytham Kamal und Dr. David C. Dorn Coordinator of this site? Confirm its status | Hanover | Germany | Recruiting |
| Onkologische Schwerpunktpraxis Coordinator of this site? Confirm its status | Hanover | Germany | Recruiting |
| Onkologische Schwerpunktpraxis Coordinator of this site? Confirm its status | Heidelberg | Germany | Recruiting |
| Onkologie Hof MVZ GmbH Coordinator of this site? Confirm its status | Hof | Germany | Recruiting |
| SHG Klinikum Idar-Oberstein Med. Klinik I: Gastroenterologie, Nephrologie, Hämatologie, Onkologie Coordinator of this site? Confirm its status | Idar-Oberstein | Germany | Recruiting |
| Dr. Vehling-Kaiser MVZ GmbH Landshut Coordinator of this site? Confirm its status | Landshut | Germany | Recruiting |
| Gemeinschaftspraxis für Hämatologie und Onkologie GbR Coordinator of this site? Confirm its status | Lebach | Germany | Recruiting |
| Onkologie UnterEms Leer-Emden-Papenburg Dr. L. Müller Coordinator of this site? Confirm its status | Leer | Germany | Recruiting |
| Hämatologie und Onkologie München-Pasing MVZ GmbH Coordinator of this site? Confirm its status | München | Germany | Recruiting |
| Praxis Dr. Michl Coordinator of this site? Confirm its status | München | Germany | Recruiting |
| Praxis Dr. med. Jens Uhlig Coordinator of this site? Confirm its status | Naunhof | Germany | Recruiting |
| MVZ Onko Medical GmbH Coordinator of this site? Confirm its status | Neustadt am Rübenberge | Germany | Recruiting |
| BAG Onkologie am Filmpark Coordinator of this site? Confirm its status | Potsdam | Germany | Recruiting |
| Praxis für Hämatologie und internistische Onkologie Coordinator of this site? Confirm its status | Ratingen | Germany | Recruiting |
| MVZ für Hämatologie und Onkologie Ravensburg GmbH - Studienzentrum Coordinator of this site? Confirm its status | Ravensburg | Germany | Recruiting |
| Schwerpunktpraxis und Tagesklinik für Hämatologie und Onkologie Coordinator of this site? Confirm its status | Regensburg | Germany | Recruiting |
| Klinikum Rosenheim Medizinische Klinik II Coordinator of this site? Confirm its status | Rosenheim | Germany | Recruiting |
| Zentrum Ambulante Onkologie Coordinator of this site? Confirm its status | Schorndorf | Germany | Recruiting |
| MVZ Kloster Paradiese GbR Schwerpunktpraxis für Hämatologie u Onkologie Coordinator of this site? Confirm its status | Soest | Germany | Recruiting |
| Onkologische Schwerpunktpraxis Speyer Coordinator of this site? Confirm its status | Speyer | Germany | Recruiting |
| Hämatologie - Onkologie - Stolberg Coordinator of this site? Confirm its status | Stolberg | Germany | Recruiting |
| Universitätsklinikum Ulm Klinik für Innere Medizin I Gastroenterologie, Nephrologie Coordinator of this site? Confirm its status | Ulm | Germany | Recruiting |
| ze:ro Praxen MVZ für Innere Medizin Weinheim Coordinator of this site? Confirm its status | Weinheim | Germany | Recruiting |
| KHOP - Kalkan Hämatologie Onkologie Palliativmedizin Coordinator of this site? Confirm its status | Wermelskirchen | Germany | Recruiting |
| MVZ für Onkologie und Urologie GmbH Coordinator of this site? Confirm its status | Wilhelmshaven | Germany | Recruiting |
| Praxis und Tagesklinik für Hämatologie/Onkologie Coordinator of this site? Confirm its status | Zittau | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.