NCT06787651Active, not recruiting
Comparison of RIMA-SVG and Ao-SVG Techniques in Coronary Artery Bypass Grafting
Comparison of RIMA-SVG and Ao-SVG Techniques in Coronary Artery Bypass Grafting : A Prospective Randomized Double-Blind Study on Graft Patency and Clinical Outcomes
Source: ClinicalTrials.gov · Last updated 6 Aug 2025
Brief summary (registry, in English)
This randomized, double-blind, single-center clinical trial was divided into two groups, RIMA-SVG and Ao-SVG, according to the surgical method. The purpose was to evaluate the effect of the RIMA-SVG surgical method in improving saphenous vein graft (SVG) patency and reducing clinical complications. A total of 300 patients will be enrolled and randomly assigned to two surgical method groups: RIMA-SVG Group (150 patients): SVGs are connected to the right internal mammary artery (RIMA). Ao-SVG Group (150 patients): The aorta is clamped, and SVGs are connected to the ascending aorta (Ao).All patients will undergo CABG on a beating heart with sequential vein grafts to bypass at least two or more coronary vessels. The primary outcome is 1-year graft patency. The secondary outcomes include neurological complications, mortality, major adverse cardiovascular events (MACE), and surgical site infection event.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 300 (estimated)
- First submitted
- 16 Jan 2025
- Start date
- 1 Feb 2025
- Primary completion date
- 1 Jun 2026
- Lead sponsor
- Second Hospital of Jilin University
- Diseases
- Coronary artery disease
- NCT number
- NCT06787651
What you commit to
- Study type: Interventional
- Planned participants: 300
- From 1 Feb 2025 to the primary completion date, 1 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with previous intracranial hemorrhage, ischemic stroke within 14 days preoperatively, or severe carotid artery stenosis.
- Patients requiring emergency surgery.
Other illness
- Patients requiring other cardiac surgeries (e.g. valve replacement, congenital heart defect surgery, or aortic dissection repair).
- Patients with active malignancy.
- Patients with active bleeding or a history of bleeding tendency.
Other
- Patients unable to provide written informed consent.
- Patients with severe stenosis of the left or right subclavian artery.
- Patients for whom aortic clamping is infeasible due to calcification of the ascending aorta.
- Patients with bilateral SVG varicosities unsuitable for grafting.
- Patients with severe hepatic dysfunction.
Who the study is looking for
- Patients aged 18 to 80 years.
- Scheduled for their first planned coronary artery bypass grafting (CABG) with at least two sequential saphenous vein grafts (SVGs).
- Able and willing to provide written informed consent.
Age in the registry: 18 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Second Hospital of Jilin University Coordinator of this site? Confirm its status | Changchun | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.