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NCT06788886Recruiting

Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases

Enhancing Brain and Mental Health Through Respiratory Training: Clinical Applications in Cancer and Neurodegenerative Disease Care for Patients and Caregivers (Breathing Study)

Source: ClinicalTrials.gov · Last updated 10 Jun 2026

Brief summary (registry, in English)

This clinical trial studies the effect of respiratory training for enhancing brain and mental health among patients with multiple sclerosis (MS) and cancer (along with their caregivers). The relationship between respiration, cardiovascular effects in the brain, mental health, and neurophysiological mechanisms are significant for patient populations facing complex health challenges, such as those with cancer and neurodegenerative disease, and their caregivers. By measuring oxygen delivery to brain tissues and cerebrospinal fluid flow, this trial may help researchers investigate the potential benefits of respiratory training for patients with MS and cancer and their caregivers.

Status (registry)
Recruiting
Study type
Interventional
Enrollment
147 (estimated)
First submitted
17 Jan 2025
Start date
5 Feb 2025
Primary completion date
18 Jan 2027
Lead sponsor
Mayo Clinic
NCT number
NCT06788886

What you commit to

  • Study type: Interventional
  • Planned participants: 147
  • From 5 Feb 2025 to the primary completion date, 18 Jan 2027
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • STUDY 1: Participants incompatible with MRI machines due to factors such as pacemakers or metallic implants.

Other illness

  • STUDY 1: Additionally, those with chronic medical conditions, including heart disease (coronary artery disease, congestive heart failure, hypertension, cardiac arrhythmia), chronic obstructive pulmonary disease (COPD), cystic fibrosis, cancer, diabetes, sleep apnea, aneurysms, and neurological conditions (epilepsy, Alzheimer's disease, Huntington' disease, essential tremor and Parkinson disease) are excluded.
  • STUDY 1: Participants with psychiatric conditions such as psychosis, suicidality, bipolar disorder, major depression, and substance use disorders are excluded.
  • STUDY 1: Participants serving as caregivers for any of the aforementioned conditions and for other illnesses such as cancer or neurological disorders, are also excluded.
  • STUDY 2: Participants incompatible with MRI machines due to factors such as pacemakers or metallic implants are excluded, as are those with chronic lung disease (chronic obstructive pulmonary disease \[COPD\], cystic fibrosis), aneurysms, and those who are pregnant.
  • STUDY 3: Participants incompatible with MRI machines due to factors such as pacemakers or metallic implants are excluded, as are those with chronic lung disease (chronic obstructive pulmonary disease \[COPD\], cystic fibrosis), aneurysms, and those who are pregnant.

Other

  • STUDY 1: Further exclusions apply to those with severe vision, hearing impairments, have a body mass index (BMI) over 30, and those who are pregnant.
  • STUDY 1: Those planning to become pregnant during the study period will be excluded.
  • STUDY 2: Those planning to become pregnant during the study period will be excluded.
  • STUDY 3: Those planning to become pregnant during the study period will be excluded.

Who the study is looking for

  • STUDY 1: Participants must be physically fit enough to perform light exercise.
  • STUDY 1: Should read and understand English well enough to consent, complete measures, and follow instructions.
  • STUDY 1: Must have access to a smartphone or tablet.
  • STUDY 2: Participants must be physically fit enough to perform light exercise.
  • STUDY 2: Cancer patients may have prostate cancer, neuroendocrine tumor, or brain cancer in any stage.
  • STUDY 2: The main focus is on pairs of cancer patients and their respective caregivers, but individual cancer patients or individual caregivers are also acceptable.
  • STUDY 2: Participants should read and understand English well enough to consent, complete measures, and follow instructions.
  • STUDY 2: They also must have access to a smartphone or tablet.
  • STUDY 3: Participants must be physically fit enough to perform light exercise.
  • STUDY 3: The patient should have multiple sclerosis.
  • STUDY 3: Participants should read and understand English well enough to consent, complete measures, and follow instructions.
  • STUDY 3: They also must have access to a smartphone or tablet.

Age in the registry: 18 years to 85 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Mayo Clinic in Rochester
Coordinator of this site? Confirm its status
RochesterUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.