NCT06789497Completed
The GABAergic Inhibitory System in Drug Resistant Epilepsy
Lovastatin Modulation of the Inhibition-excitation Balance in Temporal Lobe Onset Drug Resistant Epilepsy
Source: ClinicalTrials.gov · Last updated 23 Jan 2025
Brief summary (registry, in English)
This study aims to investigate the effect of lovastatin on neurotransmission and neuroinflammation in patients with temporal lobe onset drug resistant epilepsy. Structure: (1) Visit 1: 3 consecutive days of physiologically probing drug/placebo intake, (2) Visit 2: Outcome measures and additional evaluations in the day after the last drug/placebo intake, (3) Washout period of 4 weeks, (4) 3 consecutive days of drug/placebo intake, (5) Visit 3: Outcome measures and additional evaluations in the day after the last placebo/drug intake.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 5 (actual)
- First submitted
- 17 Jan 2025
- Start date
- 12 Jan 2020
- Primary completion date
- 1 Jan 2024
- Lead sponsor
- University of Coimbra
- Diseases
- Epilepsy
- NCT number
- NCT06789497
What you commit to
- Study type: Interventional
- Participants enrolled: 5
- From 12 Jan 2020 to the primary completion date, 1 Jan 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- history of dyslipidemia, previous use of statins or a previously documented adverse reaction to statins,
Other illness
- history of cardiovascular or cerebrovascular disease,
- implanted devices such as cardiac pacemakers or cochlear implants,
- having a vagal nerve stimulation device and the presence of other comorbid neurologic conditions
Other
- having any metal inside the head but outside the mouth,
Who the study is looking for
- diagnosis of pharmacoresistant epilepsy as defined by the International League Against Epilepsy,
- focal temporal lobe onset
- nonpregnant and nonlactating in women
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Institute of Nuclear Sciences Applied to Health Coordinator of this site? Confirm its status | Coimbra | Portugal | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.