NCT06791629Not yet recruiting
Pulsed Field Ablation Versus Radiofrequency Ablation for Persistent Atrial Fibrillation
Pulsed Field Ablation Versus Radiofrequency Ablation for Persistent Atrial Fibrillation: A Randomized, Open-label, Non-inferior Study
Source: ClinicalTrials.gov · Last updated 24 Jan 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This clinical trial aims to compare the efficacy and safety of pulsed field ablation and radiofrequency ablation to treat persistent atrial fibrillation in adults. Participants will: Undergo pulsed field ablation or radiofrequency ablation. Keep follow-up for at least 12 months.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 700 (estimated)
- First submitted
- 19 Jan 2025
- Start date
- 15 Feb 2025
- Primary completion date
- 15 Dec 2026
- Lead sponsor
- Beijing Anzhen Hospital
- Diseases
- Atrial fibrillation
- NCT number
- NCT06791629
What you commit to
- Study type: Interventional
- Planned participants: 700
- From 15 Feb 2025 to the primary completion date, 15 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently enrolled in another trial evaluating medical devices or drugs
Other illness
- Severe congenital heart disease
- History of cardiac surgery, such as coronary artery bypass grafting, mechanical valve or prosthetic valve replacement
- History of pacemaker implantation, left atrial appendage closure, or patent foramen ovale closure
- Contraindications to right or left heart catheterization
- Life expectancy \< 1 year (e.g., advanced malignancy, end-stage renal disease)
Lab values
- LVEF \< 30%
- Severe liver or kidney dysfunction (eGFR \< 15, Child-Pugh grade 3), or history of dialysis
Other
- Atrial fibrillation due to reversible causes
- Contraindications to oral anticoagulation
- Pregnancy
- Other situations where the investigator determines the subject is unsuitable for the study
Who the study is looking for
- 18-80 years
- Patients with non-valvular persistent atrial fibrillation undergoing their first catheter ablation (AF duration: 3 months to 3 years)
- Left atrial diameter on parasternal long-axis view of echocardiogram \< 50 mm
- Agree to be randomly assigned to the ablation strategy and able to follow up
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beijing Anzhen Hospital, Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.