NCT06794996CompletedPhase 2
Inaxaplin in Participants With Proteinuric APOL1 Mediated Kidney Disease With or Without Comorbidities
A Phase 2b, Open-label Study to Evaluate the Efficacy and Safety of Inaxaplin in Subjects With Proteinuric APOL1-mediated Kidney Disease With or Without Comorbidities That May Independently Contribute to Chronic Kidney Disease
Source: ClinicalTrials.gov · Last updated 20 Aug 2026
Brief summary (registry, in English)
The purpose of the study is to evaluate the efficacy, safety, and tolerability of Inaxaplin (IXP) in participants with proteinuric APOL1- mediated kidney disease (AMKD).
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 42 (actual)
- First submitted
- 23 Jan 2025
- Start date
- 4 Feb 2025
- Primary completion date
- 20 Jul 2026
- Lead sponsor
- Vertex Pharmaceuticals Incorporated
- Diseases
- Chronic kidney disease
- NCT number
- NCT06794996
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 42
- From 4 Feb 2025 to the primary completion date, 20 Jul 2026
- 35 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Uncontrolled hypertension
- Other protocol defined Inclusion/Exclusion criteria may apply.
Other
- Evidence of Focal Segmental Glomerulosclerosis (FSGS) with a known cause other than due to APOL1 risk variants
Who the study is looking for
- Participant has an APOL1 genotype of G1/G1, G2/G2, or G1/G2 obtained with a Vertex designated investigational clinical study assay
- Estimated Glomerular Filtration Rate (eGFR) of greater than or equal to (≥) 25 milliliter per minute (mL/min)/1.73m\^2 at screening
Age in the registry: 18 years to 67 years · Sex: All · Does not accept healthy volunteers
Sites (35)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Renal Associates of Baton Rouge Coordinator of this site? Confirm its status | Baton Rouge | United States | Unknown status |
| North Carolina Nephrology P.A. - Cary Office Coordinator of this site? Confirm its status | Cary | United States | Unknown status |
| UNC Clinical and Translational Research Center Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
| Columbia Nephrology Associates, PA Coordinator of this site? Confirm its status | Columbia | United States | Unknown status |
| Nephrology Associates, P.C. Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| Renal Associates LLC Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| Dallas Nephrology Associates - Dallas Landry Office Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Dallas Renal Group - 2 Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| UTSW Medical Center - Nephrology Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Dallas Renal Group - 1 Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Georgia Nephrology - Decatur Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Duke University Hospital - Children's Health Center Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
| Javara Inc./Privia Medical Group Georgia, LLC - Fayetteville Coordinator of this site? Confirm its status | Fayetteville | United States | Unknown status |
| Foundation for Sickle Cell Disease Research, LLC Coordinator of this site? Confirm its status | Hollywood | United States | Unknown status |
| Prolato Clinical Research Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Nephrology Consultants, LLC Coordinator of this site? Confirm its status | Huntsville | United States | Unknown status |
| DaVita Kidney Care - Las Vegas Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| South Florida Research Institute Coordinator of this site? Confirm its status | Lauderdale Lakes | United States | Unknown status |
| Scott Research, Inc. Coordinator of this site? Confirm its status | Laurelton | United States | Unknown status |
| Georgia Nephrology Coordinator of this site? Confirm its status | Lawrenceville | United States | Unknown status |
| LCMC Health Coordinator of this site? Confirm its status | Metairie | United States | Unknown status |
| Schiff Center for Liver Diseases Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Saint Michael's Medical Center - Peter Ho Memorial Clinic Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
| Rutgers Doctors Office Center Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
| Eastern Nephrology Associates - New Bern Office Coordinator of this site? Confirm its status | New Bern | United States | Unknown status |
| Ochsner Medical Center - New Orleans - Nephrology Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| NYC Health + Hospital/Harlem Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Tks Research, P.L.L.C. Coordinator of this site? Confirm its status | Norfolk | United States | Unknown status |
| CTR Oakwater, LLC Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Lewis Katz School of Medicine at Temple University - Section of Nephrology Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Javara Inc. /Privia Medical Group Georgia, LLC - Savannah Coordinator of this site? Confirm its status | Savannah | United States | Unknown status |
| Northwest Louisiana Nephrology, LLC - Shreveport Coordinator of this site? Confirm its status | Shreveport | United States | Unknown status |
| Javara Inc./Privia Medical Group, LLC MidAtlantic-Silver Spring, MD Coordinator of this site? Confirm its status | Silver Spring | United States | Unknown status |
| Carolina Nephrology, PA Coordinator of this site? Confirm its status | Spartanburg | United States | Unknown status |
| - Nephrology and Hypertension Associates Ltd Coordinator of this site? Confirm its status | Tupelo | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.