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NCT06794996CompletedPhase 2

Inaxaplin in Participants With Proteinuric APOL1 Mediated Kidney Disease With or Without Comorbidities

A Phase 2b, Open-label Study to Evaluate the Efficacy and Safety of Inaxaplin in Subjects With Proteinuric APOL1-mediated Kidney Disease With or Without Comorbidities That May Independently Contribute to Chronic Kidney Disease

Source: ClinicalTrials.gov · Last updated 20 Aug 2026

Brief summary (registry, in English)

The purpose of the study is to evaluate the efficacy, safety, and tolerability of Inaxaplin (IXP) in participants with proteinuric APOL1- mediated kidney disease (AMKD).

Status (registry)
Completed
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
42 (actual)
First submitted
23 Jan 2025
Start date
4 Feb 2025
Primary completion date
20 Jul 2026
Lead sponsor
Vertex Pharmaceuticals Incorporated
NCT number
NCT06794996

What you commit to

  • Study type: Interventional · Phase 2
  • Participants enrolled: 42
  • From 4 Feb 2025 to the primary completion date, 20 Jul 2026
  • 35 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Uncontrolled hypertension
    • Other protocol defined Inclusion/Exclusion criteria may apply.

Other

  • Evidence of Focal Segmental Glomerulosclerosis (FSGS) with a known cause other than due to APOL1 risk variants

Who the study is looking for

  • Participant has an APOL1 genotype of G1/G1, G2/G2, or G1/G2 obtained with a Vertex designated investigational clinical study assay
  • Estimated Glomerular Filtration Rate (eGFR) of greater than or equal to (≥) 25 milliliter per minute (mL/min)/1.73m\^2 at screening

Age in the registry: 18 years to 67 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (35)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Renal Associates of Baton Rouge
Coordinator of this site? Confirm its status
Baton RougeUnited StatesUnknown status
North Carolina Nephrology P.A. - Cary Office
Coordinator of this site? Confirm its status
CaryUnited StatesUnknown status
UNC Clinical and Translational Research Center
Coordinator of this site? Confirm its status
Chapel HillUnited StatesUnknown status
Columbia Nephrology Associates, PA
Coordinator of this site? Confirm its status
ColumbiaUnited StatesUnknown status
Nephrology Associates, P.C.
Coordinator of this site? Confirm its status
ColumbusUnited StatesUnknown status
Renal Associates LLC
Coordinator of this site? Confirm its status
ColumbusUnited StatesUnknown status
Dallas Nephrology Associates - Dallas Landry Office
Coordinator of this site? Confirm its status
DallasUnited StatesUnknown status
Dallas Renal Group - 2
Coordinator of this site? Confirm its status
DallasUnited StatesUnknown status
UTSW Medical Center - Nephrology
Coordinator of this site? Confirm its status
DallasUnited StatesUnknown status
Dallas Renal Group - 1
Coordinator of this site? Confirm its status
DallasUnited StatesUnknown status
Georgia Nephrology - Decatur
Coordinator of this site? Confirm its status
DecaturUnited StatesUnknown status
Duke University Hospital - Children's Health Center
Coordinator of this site? Confirm its status
DurhamUnited StatesUnknown status
Javara Inc./Privia Medical Group Georgia, LLC - Fayetteville
Coordinator of this site? Confirm its status
FayettevilleUnited StatesUnknown status
Foundation for Sickle Cell Disease Research, LLC
Coordinator of this site? Confirm its status
HollywoodUnited StatesUnknown status
Prolato Clinical Research Center
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HoustonUnited StatesUnknown status
Nephrology Consultants, LLC
Coordinator of this site? Confirm its status
HuntsvilleUnited StatesUnknown status
DaVita Kidney Care - Las Vegas
Coordinator of this site? Confirm its status
Las VegasUnited StatesUnknown status
South Florida Research Institute
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Lauderdale LakesUnited StatesUnknown status
Scott Research, Inc.
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LaureltonUnited StatesUnknown status
Georgia Nephrology
Coordinator of this site? Confirm its status
LawrencevilleUnited StatesUnknown status
LCMC Health
Coordinator of this site? Confirm its status
MetairieUnited StatesUnknown status
Schiff Center for Liver Diseases
Coordinator of this site? Confirm its status
MiamiUnited StatesUnknown status
Saint Michael's Medical Center - Peter Ho Memorial Clinic
Coordinator of this site? Confirm its status
NewarkUnited StatesUnknown status
Rutgers Doctors Office Center
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NewarkUnited StatesUnknown status
Eastern Nephrology Associates - New Bern Office
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New BernUnited StatesUnknown status
Ochsner Medical Center - New Orleans - Nephrology
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New OrleansUnited StatesUnknown status
NYC Health + Hospital/Harlem
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New YorkUnited StatesUnknown status
Tks Research, P.L.L.C.
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NorfolkUnited StatesUnknown status
CTR Oakwater, LLC
Coordinator of this site? Confirm its status
OrlandoUnited StatesUnknown status
Lewis Katz School of Medicine at Temple University - Section of Nephrology
Coordinator of this site? Confirm its status
PhiladelphiaUnited StatesUnknown status
Javara Inc. /Privia Medical Group Georgia, LLC - Savannah
Coordinator of this site? Confirm its status
SavannahUnited StatesUnknown status
Northwest Louisiana Nephrology, LLC - Shreveport
Coordinator of this site? Confirm its status
ShreveportUnited StatesUnknown status
Javara Inc./Privia Medical Group, LLC MidAtlantic-Silver Spring, MD
Coordinator of this site? Confirm its status
Silver SpringUnited StatesUnknown status
Carolina Nephrology, PA
Coordinator of this site? Confirm its status
SpartanburgUnited StatesUnknown status
- Nephrology and Hypertension Associates Ltd
Coordinator of this site? Confirm its status
TupeloUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.