NCT06797115Completed
Hydroxyl Free Radical Associated Effects of SGLT-2 Inhibitors in Type 2 Diabetes
Source: ClinicalTrials.gov · Last updated 28 Jan 2025
Brief summary (registry, in English)
Beyond their metabolic effect, SGLT-2 inhibitors reduce the risk of heart failure and have cardiovascular and nephroprotective effects, yet their exact mechanism of action remains unclear. This prospective study included 40 patients with type 2 diabetes whose physician initiated SGLT-2 inhibitor therapy. Prior to and after 4 weeks of the initiation of use of SGLT-2 inhibitors, in addition to routine clinical and laboratory measurements, hydroxyl free radical and neuropathic evaluations were performed.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 40 (actual)
- First submitted
- 22 Jan 2025
- Start date
- 18 Jul 2022
- Primary completion date
- 30 Jun 2024
- Lead sponsor
- University of Pecs
- Diseases
- Type 2 diabetes
- NCT number
- NCT06797115
What you commit to
- Study type: Observational
- Participants enrolled: 40
- From 18 Jul 2022 to the primary completion date, 30 Jun 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- advanced hepatic- or renal disease,
- autoimmune disease,
- malignancy,
- severe peripheral arterial disease, history of foot ulceration
- recurrent genital infections
Lab values
- neuropathies of non-diabetic etiology (i.e., hereditary, drug- or toxin-induced, untreated hypothyroidism, folate deficiency (below 3.9 µg/L), vitamin B12 deficiency (below 200 ng/L),
Other
- regular excessive alcohol consumption (more than two units in men and more than one unit per day in women - one unit being defined as 15 g of pure alcohol)
Who the study is looking for
- T2D patients
- HbA1c\<10%
- eGFR\>30ml/min/1.73 m2
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| 2nd Department of Medicine and Nephrology-Diabetes Center, University of Pécs Medical School Coordinator of this site? Confirm its status | Pécs | Hungary | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.