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NCT06799182Completed

Periodontal Disease and Colorectal Cancer

The Influence of Periodontal Disease and Periodontal Treatment on Colorectal Cancer

Source: ClinicalTrials.gov · Last updated 29 Jan 2025

Brief summary (registry, in English)

The aim of this interventional study is to determine the impact of periodontal disease and periodontal treatment on patients with colorectal cancer. The main questions were: 1. Does periodontal treatment affect the levels of C-reactive protein in the blood of patients undergoing cancer treatment? 2. Can the investigators isolate periodontal pathogenic bacteria Fusobacterium nucleatum and Porphyromonas gingivalis from the mucosa of cancerous colon tissue using the method of quantitative culture? The investigators will compare the levels of C-reactive protein in the blood of patients undergoing treatment for colorectal cancer who have received periodontal treatment with patients who have not received periodontal treatment. CRP levels will be measured during the first examination with the oncological surgeon, on the first and second day after the surgical procedure, and during the first follow-up with the oncological surgeon. Additionally, the investigators collected samples of cancerous colon mucosa from 10 participants for the attempt to isolate F. nucleatum and P. gingivalis using the quantitative culture method.

Status (registry)
Completed
Study type
Interventional
Enrollment
20 (actual)
First submitted
15 Jan 2025
Start date
25 Oct 2023
Primary completion date
30 Sept 2024
Lead sponsor
University Medical Centre Ljubljana
NCT number
NCT06799182

What you commit to

  • Study type: Interventional
  • Participants enrolled: 20
  • From 25 Oct 2023 to the primary completion date, 30 Sept 2024
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • antibiotic therapy in the last 3 months
  • chemotherapy or radiotherapy prior to surgical procedure

Other illness

  • advanced stage cancer, scheduled for palliative care

Age

  • under 18 years old

Other

  • periodontal treatment in the past 12 months
  • edentulism

Who the study is looking for

  • colorectal cancer, scheduled for surgical treatment
  • consent to participate
    • Additional inclusion Criteria fot the control group:
  • fiilled questionnaire
  • Recorded CRP results at the first examination, after surgery, and at the first follow-up examination.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
University Medical Center Ljubljana, Division of stomatology, Center for oral disease and periodontology
Coordinator of this site? Confirm its status
LjubljanaSloveniaUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.