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NCT06799897Recruiting

Natural Course of Initially Metabolic Healthy Obese Individuals (Healthy Obesity)?

Source: ClinicalTrials.gov · Last updated 30 May 2025 · Not updated for over 12 months - ask the site whether it is still open

Brief summary (registry, in English)

The main goal of this study is to gain a thorough understanding, which specific factors drive the unhealthy sequelae of obesity. Therefore, the investigators want to understand: 1. What distinguishes obese persons without metabolic diseases from those with medical diseases in a cross-sectional comparison? 2. Which factors drive the conversions from metabolically healthy obesity into a metabolically unhealthy obesity in a longitudinal approach?

Status (registry)
Recruiting
Study type
Observational
Enrollment
300 (estimated)
First submitted
18 Jul 2024
Start date
18 Jan 2023
Primary completion date
18 Jan 2026
Lead sponsor
ETH Zurich
Diseases
Obesity
NCT number
NCT06799897

What you commit to

  • Study type: Observational
  • Planned participants: 300
  • From 18 Jan 2023 to the primary completion date, 18 Jan 2026
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Medication and / or pathologies that prevent a safe execution of the fat tissue biopsies

Other illness

  • History of or planned bariatric operation
  • Medical conditions that prevent examinations and testing (e.g. symptomatic cardiovascular diseases)
  • Active Malignant tumor (\<2a remission)

Other

  • Pregnancy

Who the study is looking for

  • Signed Informed Consent Form
  • Age between 18 and 60 years
  • BMI 30-50 kg/m2
  • Knowledge of German, which requires sufficient written and allow oral patient education
  • Blood pressure \< 140/90 mmHg
  • Normal glucose metabolism
    • HbA1c \< 6.5 %
    • Fasting Glucose \< 7.0 mmol/l
  • Normal lipid metabolism
    • o LDL-cholesterol \< 5.0 mmol/l
  • ≤ 2 of the following metabolic syndrome criteria combined (excluding waist circumference)
  • TG \> 1.7 mmol/l
  • HDL-cholesterol \> 1.0 mmol/l (male) / \> 1.3 mmol/l (female)
  • Fasting glucose ≥ 5.6 mmol/l
  • BP ≥ 130/85 mmHg

Age in the registry: 18 years to 60 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
dTIP / ETH Zürich
Coordinator of this site? Confirm its status		BadenSwitzerlandRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.