NCT06800586Recruiting
Tumors and Respiratory System Diseases Due to Air Pollution: New Biomarkers of Exposure and Effects
Source: ClinicalTrials.gov · Last updated 19 Dec 2025
Brief summary (registry, in English)
This study aims to examine the exposure to atmospheric pollutants in a group of non-smoking patients suffering from lung cancer, chronic obstructive pulmonary disease (COPD), and leukemia. The exposure to atmospheric pollutants will be assessed simultaneously in a group of healthy volunteers. The ultimate goal of the study is to enhance the understanding of the mechanisms by which atmospheric pollutants act, in order to develop new tools that can help halt or at least delay the development of diseases associated with pollution.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 300 (estimated)
- First submitted
- 28 Nov 2024
- Start date
- 15 Sept 2025
- Primary completion date
- Jul 2026
- Lead sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Diseases
- COPD, Lung cancer
- NCT number
- NCT06800586
What you commit to
- Study type: Observational
- Planned participants: 300
- From 15 Sept 2025 to the primary completion date, Jul 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous and/or current diagnosis of solid tumors, myelodysplastic syndromes, myeloproliferative neoplasms
- Previous and/or current treatment with antineoplastic agents
- Healthy Volunteer Cohort to be Recruited at the Department of Medical Oncology, IRCCS AOU of Bologna:
- Previous diagnosis of solid tumors, myelodysplastic syndromes, myeloproliferative neoplasms
- Previous treatment with antineoplastic agents (alkylating agents, hydroxyurea, topoisomerase II inhibitors, lenalidomide) -Presence of pre-existing genetic conditions (Fanconi anemia, ataxia- telangiectasia, Down syndrome, xeroderma pigmentosum, Li-Fraumeni syndrome)
Other illness
- Infection with human immunodeficiency virus (HIV), human T-lymphotropic virus types 1 or 2, or Epstein-Barr virus
- Healthy Volunteer Cohort to be Recruited at the Hematology Department (Hospital-University Company, Policlinico Riuniti di Foggia):
Other
- Patient Cohort to be Recruited at the Department of Pneumology and Respiratory Intensive Care, IRCCS AOU of Bologna:
- Deficiency of alpha-1 antitrypsin (A1AT)
- Healthy Volunteer Cohort to be Recruited at the Department of Pneumology and Respiratory Intensive Care, IRCCS AOU of Bologna:
- Workers from the Department of Pneumology and Respiratory Intensive Care, IRCCS AOU of Bologna, S. Orsola Polyclinic
- Patient Cohort to be Recruited at the Department of Medical Oncology, IRCCS AOU of Bologna:
- Workers from the Department of Medical Oncology, IRCCS AOU of Bologna, S. Orsola Polyclinic
- Patient Cohort to be Recruited at the Hematology Department (Hospital-University Company, Policlinico Riuniti di Foggia):
- Workers from the Hematology Department, Hospital-University Company, Policlinico Riuniti di Foggia
Who the study is looking for
- Patient Cohort to be Recruited at the Department of Pneumology and Respiratory Intensive Care, IRCCS AOU of Bologna:
- Age ≥ 18 years
- Patients with a diagnosis of COPD of any severity (FEV1/FVC \< 0.7 after bronchodilation test)
- Non-smokers according to ISS definition: patients who declare having smoked less than 100 cigarettes (5 packs of 20) in their lifetime and are not currently smokers
- Signature of informed consent
- Healthy Volunteer Cohort to be Recruited at the Department of Pneumology and Respiratory Intensive Care, IRCCS AOU of Bologna:
- Age ≥ 18 years
- Non-smokers according to ISS definition: subjects who declare having smoked less than 100 cigarettes (5 packs of 20) in their lifetime and are not currently smokers
- Absence of comorbidities related to the study (COPD, solid tumors, leukemia) in medical history
- Workers of the IRCCS AOU of Bologna, S. Orsola Polyclinic
- Signature of informed consent
- Patient Cohort to be Recruited at the Department of Medical Oncology, IRCCS AOU of Bologna:
- Age ≥ 18 years
- Patients with a diagnosis of lung neoplasm of any histotype and stage
- Non-smokers according to ISS definition: patients who declare having smoked less than 100 cigarettes (5 packs of 20) in their lifetime and are not currently smokers
- Signature of informed consent
- Healthy Volunteer Cohort to be Recruited at the Department of Medical Oncology, IRCCS AOU of Bologna:
- Age ≥ 18 years
- Non-smokers according to ISS definition: subjects who declare having smoked less than 100 cigarettes (5 packs of 20) in their lifetime and are not currently smokers
- Absence of comorbidities related to the study (COPD, solid tumors, leukemia) in medical history
- Workers of the IRCCS AOU of Bologna, S. Orsola Polyclinic
- Signature of informed consent
- Patient Cohort to be Recruited at the Hematology Department (Hospital-University Company, Policlinico Riuniti di Foggia):
- Age ≥ 18 years
- Non-smokers according to ISS definition: patients who declare having smoked less than 100 cigarettes (5 packs of 20) in their lifetime and are not currently smokers
- Patients with a diagnosis of leukemia of any type
- Signature of informed consent
- Healthy Volunteer Cohort to be Recruited at the Hematology Department (Hospital-University Company, Policlinico Riuniti di Foggia):
- Age ≥ 18 years
- Non-smokers according to ISS definition: subjects who declare having smoked less than 100 cigarettes (5 packs of 20) in their lifetime and are not currently smokers
- Absence of comorbidities related to the study (COPD, solid tumors, leukemia) in medical history
- Workers of the Hospital-University Company, Policlinico Riuniti di Foggia
- Signature of informed consent
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna Coordinator of this site? Confirm its status | Bologna | Italy | Recruiting |
| Respiratory and Critical Care Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna Coordinator of this site? Confirm its status | Bologna | Italy | Recruiting |
| Ematology Unit, Azienda Ospedaliero-Universitaria, Policlinico Riuniti di Foggia Coordinator of this site? Confirm its status | Foggia | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.