NCT06801899Recruiting
ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Distal Cholangiocarcinoma, and Ampullary Cancer
ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Distal Cholangiocarcinoma, and Ampullary Cancer: a Multi-centric Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 12 Aug 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn if total removal of the pancreas is a preferable alternative to partial removal in patients with cancer of the pancreatic head who are at high risk of pancreatic leakage. The main question it aims to answer is: Does total pancreas removal improve survival without reducing quality of life compared to partial removal? The only study specific procedures are the collection of 2 blood samples (7.5ml for each time point, preoperatively and during the hospitalisation) and the completion of the questionnaires.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 170 (estimated)
- First submitted
- 24 Jan 2025
- Start date
- 1 Jun 2026
- Primary completion date
- Oct 2030
- Lead sponsor
- Insel Gruppe AG, University Hospital Bern
- NCT number
- NCT06801899
What you commit to
- Study type: Interventional
- Planned participants: 170
- From 1 Jun 2026 to the primary completion date, Oct 2030
- 10 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Pregnancy. A beta-Human Chorionic Gonadotropin (bHCG) pregnancy test must to be performed for women of child-bearing potential (defined as premenopausal women who have not undergone surgical sterilization)
Other illness
- Duodenal carcinoma, ampullary cancer (intestinal type), neuroendocrine tumors, benign tumors, chronic pancreatitis
- Medical conditions that do not allow appreciation of the nature, scope, and possible consequences of the trial as judged by the investigator
- Inability to follow the study procedures, e.g., due to psychological disorders, dementia, etc.
Who the study is looking for
- Adult patients (age ≥ 18 years) scheduled to undergo PD for highly suspected or histologically proven, resectable pancreatic ductal adenocarcinoma (PDAC), distal cholangiocarcinoma (DCC), and/or ampullary cancer (pancreaticobiliary type)
- Suspected pancreas anastomosis at high-risk for development of a postoperative pancreatic fistula (POPF) (grade "D" according to Schuh et al. (29): Estimation by CT scan, MRI, and/or Endoscopic Ultrasound
- Written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (10)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of General and Visceral Surgery, Kantonsspital Aarau Coordinator of this site? Confirm its status | Aarau | Switzerland | Recruiting |
| Department of Surgery, Kantonsspital Baden Coordinator of this site? Confirm its status | Baden | Switzerland | Recruiting |
| Department of Visceral Surgery, University Hospital Basel Coordinator of this site? Confirm its status | Basel | Switzerland | Recruiting |
| Inselspital, Bern University Hospital Coordinator of this site? Confirm its status | Bern | Switzerland | Recruiting |
| Department of Visceral Surgery, University Hospital Geneva Coordinator of this site? Confirm its status | Geneva | Switzerland | Recruiting |
| Department of General, Visceral, Endocrine and Transplantation Surgery, Kantonsspital St. Gallen Coordinator of this site? Confirm its status | Sankt Gallen | Switzerland | Recruiting |
| Department of Surgery and Transplantation, University Hospital Zürich Coordinator of this site? Confirm its status | Zurich | Switzerland | Recruiting |
| Department of Surgery, Stadtspital Triemli Zürich Coordinator of this site? Confirm its status | Zurich | Switzerland | Recruiting |
| Department of General, Visceral and Transplantation Surgery, University Hospital Münster Coordinator of this site? Confirm its status | Münster | Germany | Recruiting |
| Department of General and Visceral Surgery, University Hospital Ulm Coordinator of this site? Confirm its status | Ulm | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.