NCT06803771Recruiting
Surveillance of Pancreatic Health After Diabetes Diagnosis
An Interventional Study to Evaluate the cfDNA Pancreatic Cancer Test (Avantect) in the Early Detection of Pancreatic Cancer in Participants With Newly Diagnosed Diabetes Mellitus or Newly Elevated HbA1c
Source: ClinicalTrials.gov · Last updated 28 Sept 2026
Brief summary (registry, in English)
The goal of this interventional study is to evaluate if the novel diagnostic blood test, called Avantect can early detect pancreatic cancer in patients diagnosed with type 2 diabetes or with elevated sugar levels within the last 200 days. Participants will: * attend 3 study visits over 12 months time * provide a blood sample at each study visit * complete an anxiety questionnaire at each visit.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 5000 (estimated)
- First submitted
- 27 Jan 2025
- Start date
- May 2025
- Primary completion date
- Jul 2029
- Lead sponsor
- University Hospital Southampton NHS Foundation Trust
- Diseases
- Pancreatic cancer, Type 2 diabetes
- NCT number
- NCT06803771
What you commit to
- Study type: Interventional
- Planned participants: 5000
- From May 2025 to the primary completion date, Jul 2029
- 31 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any known pancreatic surgery (not including ERCP), or other major surgery requiring anaesthesia within 3 months
- Solid organ transplant recipient
Other illness
- A history of pancreatic cancer, pancreatic neuroendocrine tumour (pNET) or Pancreatitis
- Under investigation for or confirmed pancreatic cancer
- Any invasive solid or haematological cancer in the past 3 years, including cancer recurrence after treatment in the last 3 years
Lab values
- Prior type I or type II DM diagnosis or an initial HbA1c ≥ 48 mmol/mol or 6.5% obtained prior to the 200-day inclusion window, except gestational elevated HbA1c.
Other
- Under investigation/surveillance for pancreatic cyst
- BMI \> 40 at the time of consent
- Blood transfusion within 1 month
- Currently pregnant
- Needing dialysis
Who the study is looking for
- 50 - 84 years of age at the time of enrolment (within year of birth, not month of birth)
- Confirmed type 2 DM diagnosis established within the last 200 days or an initial elevated HbA1c ≥ 48 mmol/mol or 6.5% obtained within the last 200 days. This includes people who have a first elevated HbA1c (≥ 48 mmol/mol or 6.5%) within the last 200 days, even if subsequent HbAc1 measurements return to the the normal range.
- Willing to provide up to 30 mL of blood for each study visit
- Willing and eligible to undergo MRI or CT scan
- Understands the study process and is willing to take part in the study and sign the informed consent form
Age in the registry: 50 years to 84 years · Sex: All · Does not accept healthy volunteers
Sites (31)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ashton Medical Group Coordinator of this site? Confirm its status | Ashton-under-Lyne | United Kingdom | Active, not recruiting |
| Yardley Wood Health Centre Coordinator of this site? Confirm its status | Birmingham | United Kingdom | Recruiting |
| Bournemouth Research Hub Coordinator of this site? Confirm its status | Bournemouth | United Kingdom | Active, not recruiting |
| Brockwood Medical Practice Coordinator of this site? Confirm its status | Brockham | United Kingdom | Recruiting |
| Eastham Group Practice Coordinator of this site? Confirm its status | Bromborough | United Kingdom | Recruiting |
| Peel Croft Surgery Coordinator of this site? Confirm its status | Burton-on-Trent | United Kingdom | Recruiting |
| Integrated Care Partnership/ The Old Cottage Hospital Coordinator of this site? Confirm its status | Epsom | United Kingdom | Recruiting |
| South Leicestershire Medical Group Coordinator of this site? Confirm its status | Kibworth Beauchamp | United Kingdom | Recruiting |
| Kingswinford Medical Practice Coordinator of this site? Confirm its status | Kingswinford | United Kingdom | Recruiting |
| Park Medical Centre Coordinator of this site? Confirm its status | Leek | United Kingdom | Recruiting |
| Forest Medical Group Coordinator of this site? Confirm its status | Leicester | United Kingdom | Recruiting |
| The Cuckoo Lane Practice Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| South Westminster Centre Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Willesden Medical Centre Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Maidstone and Tunbridge Wells NHS Trust Coordinator of this site? Confirm its status | Maidstone | United Kingdom | Recruiting |
| Bodey Medical Centre Coordinator of this site? Confirm its status | Manchester | United Kingdom | Active, not recruiting |
| The Maples Medical Centre Coordinator of this site? Confirm its status | Manchester | United Kingdom | Active, not recruiting |
| Bowland Medical Practice Coordinator of this site? Confirm its status | Manchester | United Kingdom | Active, not recruiting |
| King's Mill Hospital (Sherwood Forest) Research Van Coordinator of this site? Confirm its status | Nottingham | United Kingdom | Recruiting |
| Portsmouth Research Hub Coordinator of this site? Confirm its status | Portsmouth | United Kingdom | Active, not recruiting |
| Hazelvalley Family Practice Coordinator of this site? Confirm its status | Rossendale | United Kingdom | Recruiting |
| Pembroke Centre (Hillingdon) Coordinator of this site? Confirm its status | Ruislip | United Kingdom | Recruiting |
| Ashfields Primary Care Centre Coordinator of this site? Confirm its status | Sandbach | United Kingdom | Active, not recruiting |
| Southampton Research Hub (Shirley Research Hub) Coordinator of this site? Confirm its status | Southampton | United Kingdom | Active, not recruiting |
| Moorgreen Hospital Coordinator of this site? Confirm its status | Southampton | United Kingdom | Recruiting |
| Trinity Court Surgery Coordinator of this site? Confirm its status | Stratford-upon-Avon | United Kingdom | Recruiting |
| Balance Street Health Centre Coordinator of this site? Confirm its status | Uttoxeter | United Kingdom | Recruiting |
| Civic Centre Coordinator of this site? Confirm its status | Uxbridge | United Kingdom | Recruiting |
| Quinton Practice Coordinator of this site? Confirm its status | Walsall | United Kingdom | Recruiting |
| Warlingham Green Medical Practice Coordinator of this site? Confirm its status | Warlingham | United Kingdom | Recruiting |
| Weymouth Research Hub Coordinator of this site? Confirm its status | Weymouth | United Kingdom | Active, not recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.