NCT06805643Not yet recruiting
Dixon MRI Imaging Histology for Predicting Postoperative Infection in Posterior Lumbar Fusion for Myasthenia Gravis
Source: ClinicalTrials.gov · Last updated 3 Feb 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Sarcopenia is an age-related condition that manifests itself as a persistent decrease in muscle mass and function, which may lead to decreased physical function, increased risk of disease, and reduced quality of life. In surgical patients, sarcopenia has been shown to be associated with increased postoperative complications, prolonged hospitalization, and decreased survival. In patients undergoing lumbar fusion, the presence of sarcopenia may increase the risk of postoperative infection.Lumbar fusion is a common procedure to treat lumbar spine disorders such as lumbar disc herniation, lumbar spondylolisthesis, or lumbar spinal stenosis. However, this procedure is associated with a high rate of complications, especially postoperative infections, which can lead to reoperation, prolonged hospitalization, and even affect patient survival. In recent years, more and more studies have found a significant association between sarcopenia and postoperative infections after lumbar fusion surgery.Imagingomics belongs to a branch of machine learning, which is the process of acquiring images from various imaging devices such as CT, MRI and ultrasound, outlining the region of interest through image segmentation, extracting the features of the image within the region of interest, downscaling the features, and finally building an imagingomics model. MRI Imagingomics, utilizing its rich data information, has shown great potential for application in several medical fields. Among them, the accuracy of Dixon MRI imaging histology in muscle mass and texture assessment makes it particularly important in predicting postoperative infections.Based on this, it is reasonable to believe that Dixon MRI imaging histology can be a powerful tool to help us predict a patient's risk of postoperative infection.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 1300 (estimated)
- First submitted
- 28 Jan 2025
- Start date
- 1 Feb 2025
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- The First People's Hospital of Yunnan
- Diseases
- Myasthenia gravis
- NCT number
- NCT06805643
What you commit to
- Study type: Observational
- Planned participants: 1300
- From 1 Feb 2025 to the primary completion date, 31 Dec 2025
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- The patient has had other spinal surgery within the last 6 months.
Other illness
- Patients with serious other medical conditions, such as heart disease, kidney disease or liver disease, which may affect their post-operative recovery.
- Patients have known immune system disorders or are on immunosuppressive therapy, which may affect their risk of infection.
Other
- The patient has contraindications to MRI, such as implanted metal devices (e.g., pacemakers) or severe claustrophobia.
Who the study is looking for
- Male and female patients over 18 years of age.
- Inclusion of patients with sarcopenia is subject to the definition and diagnostic criteria of the European Consensus on Definition and Diagnosis of Sarcopenia.
- The patient underwent posterior lumbar fusion and had a Dixon MRI scan within 2 weeks prior to surgery.
- Patients were able to understand the purpose and procedures of the study and were willing to sign an informed consent form.
- The patient's clinical consultation and follow-up information was complete.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.