NCT06805734Recruiting
Natural History With Focus on Oncological Risk Evaluation in Pediatric Patients With PTEN Pathogenic Variants
Natural History With Focus on Oncological Risk Evaluation in Pediatric Patients With PTEN Pathogenic Variants - Observational Study
Source: ClinicalTrials.gov · Last updated 12 Feb 2026
Brief summary (registry, in English)
This is an observational study in pediatric patientis carryng PTEN pathogenic variants aimed to define oncological risk in children and provide a deeper insight of the clinical course, establishing an updated follow-up protocol.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 50 (estimated)
- First submitted
- 10 Dec 2024
- Start date
- 1 Aug 2024
- Primary completion date
- Jul 2029
- Lead sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
- NCT number
- NCT06805734
What you commit to
- Study type: Observational
- Planned participants: 50
- From 1 Aug 2024 to the primary completion date, Jul 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Refuse to undergo the exams of the protocol assessment at the diagnosis
- PTEN non-pathogenic variants (VOUS or benign/likely benign vatiants)
- No signed informed consent
Who the study is looking for
- PTEN pathogenic variants (class 4/5 SNV, gene deletion, intragenic duplication/deletion)
- Pediatric patients (\<18 years old) and their affected relatives, male/female, all ethnicities
- The legal representative must agree to follow the screening protocol
- Informed consent signed by the legal representative
Age in the registry: - to 17 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fondazione IRCCS Istituto Neurologico Carlo Besta Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.