NCT06814275Recruiting
Project neuroARTEMIS
Project ARTEMIS: A Mechanistic Clinical Trial of Neuroimmune Pathways.
Source: ClinicalTrials.gov · Last updated 3 Sept 2026
Brief summary (registry, in English)
The purpose of this research is to understand how chronic stress affects the way our brain and immune systems function, and in turn how this affects the way people feel, think, and behave. By learning more about how these processes work, the hope is to be able to develop better treatments to help with problems like depression and substance use. This study is intended for individuals that are HIV positive, currently taking prescription antiretroviral medications, and use stimulants. Through this intervention, the aim is to determine if this positive affect intervention can lead to reductions in stimulant use and depressed mood.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 189 (estimated)
- First submitted
- 3 Feb 2025
- Start date
- 29 Apr 2025
- Primary completion date
- 31 May 2028
- Lead sponsor
- Wake Forest University Health Sciences
- Diseases
- HIV
- NCT number
- NCT06814275
What you commit to
- Study type: Interventional
- Planned participants: 189
- From 29 Apr 2025 to the primary completion date, 31 May 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prescription for immunomodulatory medications or other immunotherapy
- If applicable, on antidepressant medication regimen for at least 2 months
Other illness
- Acute brain infection (e.g., neurosyphilis, toxoplasmosis)
- Acutely symptomatic bipolar I or psychotic disorder
Other
- Any MRI contraindications
Who the study is looking for
- 18-59 years old
- Weekly use of stimulants reported in the past month or a score of 4 or more on the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST)
- Confirmed HIV diagnosis
- Current receipt of daily oral antiretroviral therapy (ART) medication
- English fluency/literacy
Age in the registry: 18 years to 59 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Wake Forest University School of Medicine Coordinator of this site? Confirm its status | Winston-Salem | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.