NCT06814990Recruiting
Acquisition of Cardiac Function Parameters in MRI and Echocardiography in Patients With Ethyltoxic Liver Cirrhosis and Transjugular Intrahepatic Portosystemic Shunt (TIPSS) Placement
Erfassung Kardialer Funktionsparameter in MRT Und Echokardiographie Bei Patienten Mit Ethyltoxischer Leberzirrhose Und transjugulärer Intrahepatischer Portosystemischer Shunt (TIPSS)-Anlage
Source: ClinicalTrials.gov · Last updated 4 Aug 2026
Brief summary (registry, in English)
The aim of this clinical trial is to investigate the development of cardiac decompensation following transjugular intrahepatic portosystemic shunt (TIPSS) implantation in order to draw conclusions for future treatment methods or exclusion criteria prior to TIPS implantation. The main questions to be answered are: How often do symptoms of cardiac decompensation develop over a one year period? What laboratory, clinical or imaging morphological changes are associated with this? In addition to the standardised clinical procedure for TIPSS implantation, participants will undergo 3 cardiac magnetic resonance imaging (MRI), extended echocardiographic examinations (both just before, 3 days after and 3 months after implantation) and laboratory chemistry tests for specific endothelial and inflammatory markers (just before, on the day of implantation, 1 day after, 1, 3, 6 and 12 months after implantation).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 13 Nov 2024
- Start date
- 19 Apr 2024
- Primary completion date
- 19 Apr 2027
- Lead sponsor
- Stephanie Gräger
- Diseases
- Fatty liver disease (MASLD/MASH)
- NCT number
- NCT06814990
What you commit to
- Study type: Interventional
- Planned participants: 80
- From 19 Apr 2024 to the primary completion date, 19 Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Implants not suitable for magnetic resonance imaging
Other illness
- Patient in critical condition or incompliant
Other
- Pregnancy
- Medical/personal reasons against magnetic resonance imaging (claustrophobia, patient cannot lie flat or follow breathing commands)
Who the study is looking for
- Age 18 to 99 years
- Written informed consent of the patient
- Decompensated liver cirrhosis, defined by clinical, imaging or laboratory criteria
- Patient receives an elective TIPSS in the appropriate clinical context at the JUH
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Jena University Hospital Coordinator of this site? Confirm its status | Jena | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.