NCT06819475Recruiting
Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors
Source: ClinicalTrials.gov · Last updated 17 Sept 2026
Brief summary (registry, in English)
The participants are being asked to take part in this trial, because the participant is a survivor of childhood cancer or agreed to be part of a volunteer group to understand the relation between cancer and cancer treatment and muscle weakness in survivors of Acute Lymphoblastic Leukemia (ALL). ALL is cancer of the blood and bone marrow. Primary Objective • To compare muscle mtOXPHOS activity and satellite cell content among ALL survivors and controls. Secondary Objective * To evaluate the association between muscle mtOXPHOS, muscle satellite cell content and physical performance in ALL survivors. * To evaluate the association of muscle morphology and epigenetics with muscle mtOXPHOS in ALL survivors.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 8 Jan 2025
- Start date
- 2 Jun 2025
- Primary completion date
- Jul 2027
- Lead sponsor
- St. Jude Children's Research Hospital
- Diseases
- Acute lymphoblastic leukaemia
- NCT number
- NCT06819475
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 2 Jun 2025 to the primary completion date, Jul 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Survivor-Participant has history of cranial radiation.
- Survivor- or Control-Participant is allergic to local anesthetic (i.e., lidocaine, bupivacaine).
- Survivor- or Control-Participant has a current history of peripheral motor neuropathy.
Other
- Survivor- or Control-Participant has implanted medical devices or metal that would interfere with MRI or MRS
- Female Survivor- or Control-Participant is pregnant.
- Survivor- or Control-Participant is taking anticoagulants (e.g. aspirin, apixaban, coumadin, edoxaban, rivaroxaban)
- Survivor- or Control-Participant weighs more than 300 pounds.
- Survivor- or Control-Participant cannot lie flat on his/her back for 90 minutes or longer
Who the study is looking for
- Survivor- or Control-Participant is age 18 years old or older at time of consent and enrolled in SJLIFE.
- Survivor- Participant is childhood ALL survivor
- Survivor- or Control Participant has low muscle mass as defined by relative lean mass z-score of less than or equal to -0.5 SD (lean mass divided by height in meters squared).
- Survivor - Participant is able and willing to give informed consent
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St. Jude Children's Research Hospital Coordinator of this site? Confirm its status | Memphis | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.