NCT06820944Completed
Theobromine From Cocoa and Cardiovascular Risk Factors
Theobromine Consumption From Cocoa and Cardiovascular Risk Factors in Humans: Evidence for Health Claims
Source: ClinicalTrials.gov · Last updated 18 Mar 2026
Brief summary (registry, in English)
The goal of this clinical trial is to examine whether consumption of dark chocolate affects blood pressure and a cardiovascular risk factor called trimethylamine N-oxide in Thai male participants with hypertension. The main questions it aims to answer are: Can consumption of dark chocolate lower blood pressure? Can consumption of dark chocolate lower blood trimethylamine N-oxide? Researchers will compare dark chocolate to white chocolate to see if the effects are due to theobromine (a key bioactive compound in dark chocolate). Participants will consume either 100 g 72% dark chocolate bar or 80 g white chocolate bar daily for 14 days, rest for 7 days, and then switch to the other type of chocolate.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 53 (actual)
- First submitted
- 6 Feb 2025
- Start date
- 15 Feb 2025
- Primary completion date
- 30 Apr 2025
- Lead sponsor
- Chiang Mai University
- Diseases
- High blood pressure
- NCT number
- NCT06820944
What you commit to
- Study type: Interventional
- Participants enrolled: 53
- From 15 Feb 2025 to the primary completion date, 30 Apr 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Take medicine to lower cholesterol and triglyceride levels, treat high blood pressure, or diabetes.
- Have chronic diseases.
Other
- Cannot drink beverages and consume foods that have caffeine.
- Have liver and kidney inflammation.
- Use antibiotics within 1 month of study.
- Use choline or probiotic supplements regularly within 1 month of study.
- Consume more than 30 alcoholic drinks per week.
Who the study is looking for
- Male
- Age between 35 to 70 years
- BMI less than 30 kg/m\^2
- Systolic blood pressure between 130 to 159 mmHg or Diastolic blood pressure between 85 to 99 mmHg.
- Do not smoke.
Age in the registry: 35 years to 70 years · Sex: Male · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Research Institute for Health Sciences, Chiang Mai University Coordinator of this site? Confirm its status | Mueang | Thailand | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.