NCT06823843CompletedPhase 4
The Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow
The Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow: A Randomised, Placebo-controlled, Mechanistic Trial
Source: ClinicalTrials.gov · Last updated 28 Mar 2025
Brief summary (registry, in English)
The goal of this clinical trial is to investigate the effect of sublingual nitroglycerin on absolute coronary blood flow in adult patients undergoing coronary angiography. The main questions it aims to answer are: * Does sublingual nitroglycerin change absolute coronary blood flow compared to placebo? * What is the effect of sublingual nitroglycerin on important cardioavascular parameters such as coronary pressure and resistance? Researchers will compare the sublingual nitroglycerin group to the placebo group to see if nitroglycerin leads to significant changes in coronary blood flow and microvascular function. Participants will: * Receive either sublingual nitroglycerin or a placebo during coronary angiography. * Undergo coronary blood flow measurements before and after the intervention using standardized assessment techniques.
- Status (registry)
- Completed
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 40 (actual)
- First submitted
- 4 Feb 2025
- Start date
- 1 Jul 2024
- Primary completion date
- 30 Sept 2024
- Lead sponsor
- VZW Cardiovascular Research Center Aalst
- Diseases
- Coronary artery disease
- NCT number
- NCT06823843
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 40
- From 1 Jul 2024 to the primary completion date, 30 Sept 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of vasoactive medications within 24 hours of coronary angiography
Other illness
- Clinical signs or symptoms of congestive heart failure
- Severe valvular heart disease requiring either surgical or percutaneous intervention
- History of coronary artery bypass grafting
- Significant arrhythmia
Other
- ≥1 severe stenosis (defined as a diameter stenosis \>70%)
- Tortuous coronary anatomy in which wire manipulation could be complex
Who the study is looking for
- Referred for invasive coronary angiography (ICA) for suspected coronary artery disease
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| OLV Cardiovascular Center Aalst Coordinator of this site? Confirm its status | Aalst | Belgium | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.