NCT06824415Recruiting
Sleep TMS for Depression
Optimizing Depression Treatment Through Sleep-state Brain Stimulation
Source: ClinicalTrials.gov · Last updated 23 Jun 2026
Brief summary (registry, in English)
The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 55 (estimated)
- First submitted
- 7 Feb 2025
- Start date
- 1 May 2025
- Primary completion date
- 30 May 2028
- Lead sponsor
- Stanford University
- Diseases
- Depression
- NCT number
- NCT06824415
What you commit to
- Study type: Interventional
- Planned participants: 55
- From 1 May 2025 to the primary completion date, 30 May 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Significant head injury/neurological disorder
Other
- Intellectual disability
- Pregnancy or postpartum
- TMS/MRI contraindications
- Active substance use/suicidal ideation
Who the study is looking for
- Adults ages 18-65 years
- Current Major Depressive Disorder (MDD) diagnosis
- Failed ≥1 antidepressant medication
- Moderate-to-severe depression
- Stable antidepressant medication dose for ≥ 6 weeks prior to enrollment
- Healthy control participants are adults ages 18-65 years without current MDD symptoms, not taking antidepressant or antipsychotic medications, and without major psychiatric, neurological, substance use, medical conditions affecting brain function, or TMS/MRI contraindications.
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Stanford University Coordinator of this site? Confirm its status | Stanford | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.