NCT06824818Recruiting
Study to Assess the Feasibility of Stopping Prostate Cancer Treatment Early in Elderly Patients
A Feasibility Trial of LHRH Agonist Discontinuation in Elderly Prostate Cancer Patients
Source: ClinicalTrials.gov · Last updated 1 Oct 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This study seeks to identify if it is feasible to stop Luteinizing Hormone-Releasing Hormone (LHRH) Agonist Therapy in elderly men with prostate cancer. We hypothesize that elderly prostate cancer patients on long term androgen ablation with LHRH agonists will be permanently castrated and do not require ongoing LHRH agonist therapy. Participants will be monitored by testosterone testing throughout study.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 155 (estimated)
- First submitted
- 31 Jan 2025
- Start date
- Jun 2026
- Primary completion date
- Dec 2026
- Lead sponsor
- University of Chicago
- Diseases
- Prostate cancer
- NCT number
- NCT06824818
What you commit to
- Study type: Interventional
- Planned participants: 155
- From Jun 2026 to the primary completion date, Dec 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- none
Who the study is looking for
- Prostate cancer with \>3 years of LHRH agonist therapy.
- Age ≥70 years.
- ECOG performance status ≤2
- Baseline testosterone of \< 20 ng/ml
- No prior chemotherapy or Lu-PSMA (unless survival predictions are favorable).
- Ability to understand and sign informed consent.
Age in the registry: 70 years to - · Sex: Male · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UChicago Medicine Comprehensive Cancer Center Coordinator of this site? Confirm its status | Chicago | United States | Not yet recruiting |
| The University of Illinois at Chicago (UIC) Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.