NCT06825078Recruiting
Performance of Lung MRI Combined to Synthetic CT in the Follow-up of Lung Nodules
Source: ClinicalTrials.gov · Last updated 9 Jul 2026
Brief summary (registry, in English)
Lung cancer screening trials using low-dose chest CT scans have shown a significant reduction of cancer related mortality in subjects at high risk of lung cancer. However, high rate of false positives and overdiagnosis have led to invasive methods, which are not without risks. Evaluation of lung nodules using lung MRI with ultra short echo time sequences (UTE) has been found comparable to chest CT scans. Moreover, MRI has the advantage of multiparametric characterization of lesions using different tissue contrasts. Following the recommendation of the French National Authority for Health (HAS) to evaluate new methods of lung cancer screening, this prospective single center pilot study is designed to evaluate the performance of multiparametric lung MRI combined to synthetic CT in the diagnosis of lung cancer in heavily smokers or ex-smokers professionally exposed to carcinogens
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 31 Jan 2025
- Start date
- 12 Feb 2025
- Primary completion date
- Feb 2029
- Lead sponsor
- University Hospital, Bordeaux
- Diseases
- Lung cancer
- NCT number
- NCT06825078
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 12 Feb 2025 to the primary completion date, Feb 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Subject who had already undergone a chest scan less than a year previously
- Contra-indication to MRI (Pace maker, implants, claustrophobia…)
Other illness
- Subject with signs of lung cancer
- Subject with history of lung cancer
- Presence of severe life-threatening comorbidities at 6 months (recent CVA, recent discovery of advanced stage cancer)
Age
- No exposure to tobacco or insufficient exposure to tobacco or cessation \> 15 years.
Other
- No exposure to occupational lung carcinogens according to the predefined criteria.
- Pregnant or breastfeeding woman
- Poor understanding of French
- Subject under legal protection
Who the study is looking for
- Subject aged between 55 and 74 years
- High risk of developing lung cancer: by a combination of exposure to lung carcinogens and smoking (exposure to tobacco at the rate of 30 packs/year or cessation \< 15 years)
- Presence of at least one lung solid nodule ≥ 5mm on the initial scan.
- Subject able and willing to complete all scheduled visits and assessments.
- Subject with health insurance.
- Signed informed consent.
Age in the registry: 55 years to 74 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU Bordeaux Coordinator of this site? Confirm its status | Pessac | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.