NCT06827379Enrolling by invitation
Acute Effects of Inspiratory Muscle Training on Peripheral Muscle Metabolism and Autonomic Response in COPD Patients
Acute Effects of Inspiratory Muscle Training With Different Loads on Peripheral Muscle Metabolism and Autonomic Response in COPD Patients: A Randomized Crossover Trial
Source: ClinicalTrials.gov · Last updated 23 May 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The study will evaluate the acute effects of inspiratory muscle training (IMT) on peripheral muscle metabolism and autonomic response in patients with chronic obstructive pulmonary disease (COPD). This is a randomized, crossover study, with blinding of the evaluator and the researcher responsible for the statistical analysis. Participants will be divided into three groups at different times: TMI- strength (F), TMI to gain inspiratory muscle strength; IMT- resistance (R), IMT for improving inspiratory muscle resistance; and TMI sham. All participants randomized in the study will participate in the three groups, with a minimum interval of 48 hours between participation in each group. Randomization will determine the sequence of participation in the three groups for all participants. For statistical analysis, an intention-to-treat approach will be used, and the groups will be compared using the Student's t test for continuous variables or the chi-square test for categorical variables. A split-plot ANOVA with repeated measures will be used for primary outcomes, and analysis of covariance will be conducted to identify differences between groups using baseline scores as covariates. Effect sizes and confidence intervals will be calculated using eta squared. It is expected that IMT applied at different loads can promote effects on vascular function, peripheral muscle metabolism and the response of the autonomic nervous system in patients with COPD, which can greatly contribute to the understanding of the physiological effects of this therapy and support its prescription. as a therapeutic intervention in the rehabilitation of patients with pulmonary diseases.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 30 Jan 2025
- Start date
- 1 Mar 2025
- Primary completion date
- 1 Dec 2025
- Lead sponsor
- Federal University of Paraíba
- Diseases
- COPD
- NCT number
- NCT06827379
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 1 Mar 2025 to the primary completion date, 1 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who have experienced any health issue or had a COPD exacerbation in the previous month will also be excluded to ensure that the patient's symptoms are stable.
Other illness
- Presence of psychiatric disorders or cognitive impairments, progressive neurological disorders, cancer, or chronic pain;
- Cognitive impairment or inability to understand commands.
Other
- Inability to perform the IMT protocol and/or functional tests;
Who the study is looking for
- Patients with COPD according to the Global Initiative for COPD (GOLD, 2023);
- Aged 40 years or older and under 75 years;
- Providing both oral and written informed consent.
Age in the registry: 40 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Universidade Federal da Paraíba Coordinator of this site? Confirm its status | João Pessoa | Brazil | Unknown status |
Related publications
- Acute Effects of Inspiratory Muscle Training with Different Loads on Peripheral Muscle Oxygenation Kinetics and Autonomic Response in Patients with COPD: A Protocol for a Randomized Crossover Study.Int J Chron Obstruct Pulmon Dis · 2026 · PMID 42904147
- Dizziness, Lower Limb Weakness, and Falls in COPD: A Prospective Longitudinal Pilot Study Using Monthly Home Diaries.Physiother Res Int · 2026 · PMID 42910412
- Acute Effect of Inspiratory Muscle Training on Peripheral Tissue Oxygenation Behavior in Individuals With COPD: A Randomized Crossover Study.Physiother Res Int · 2026 · PMID 41738531
This page is information, not medical advice. Discuss any trial with your doctor.