NCT06835166Completed
Effect of Intraoperative Position Change on Hemodynamics and Electrocardiography
Effect of Intraoperative Position Change on Hemodynamics and Cardiac Electrophysiological Balance Index in Morbidly Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy
Source: ClinicalTrials.gov · Last updated 16 Jan 2026
Brief summary (registry, in English)
The combined effects of obesity-related cardiac structure and function changes, comorbidities, pneumoperitoneum technique, and reverse Trendelenburg position may complicate anesthesia management by affecting intraoperative hemodynamics and cardiac function. Increased intra-abdominal pressure leads to various physiological changes through mechanical and neurohormonal responses. Furthermore, pneumoperitoneum and reverse Trendelenburg position are reported to stimulate the sympathetic nervous system and increase the risk of cardiac arrhythmia. Obesity-related changes in cardiac structure and function have been shown to predispose to cardiac conduction and repolarization disorders. It has also been stated that obesity directly affects cardiac electrophysiology. Moreover, obese patients may have hidden risks associated with the development of cardiac arrhythmias due to the adverse contributions of the cardiovascular effects of anesthesia, pneumoperitoneum, and patient positioning during laparoscopic intervention. The index of cardiac electrophysiological balance (iCEB) is a non-invasive marker calculated by the QT/QRS ratio that can predict malignant ventricular arrhythmias. The aim of this study was to investigate the effects of intraoperative patient positions on hemodynamics and the index of cardiac electrophysiological balance (iCEB) during laparoscopic sleeve gastrectomy in morbidly obese patients.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 80 (actual)
- First submitted
- 6 Feb 2025
- Start date
- 10 Feb 2025
- Primary completion date
- 25 Apr 2025
- Lead sponsor
- Firat University
- Diseases
- Obesity
- NCT number
- NCT06835166
What you commit to
- Study type: Observational
- Participants enrolled: 80
- From 10 Feb 2025 to the primary completion date, 25 Apr 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Emergency laparoscopic sleeve gastrectomy surgery (stump leakage, etc.)
- Secondary surgery in addition to elective laparoscopic sleeve gastrectomy
- Patients with previous recurrent abdominal surgery
Other illness
- Renal and liver failure
Lab values
- Preoperative arrhythmia and heart failure (ejection fraction \< 30%)
Other
- Patient refusal to participate in the study
- Those who underwent revision laparoscopic sleeve gastrectomy
- Patients with electrolyte imbalance
- Direct laryngoscopy in ramp position
- Multiple intubation attempts due to difficult intubation
- Patients who require \> 8 ml/kg for tidal volume
Who the study is looking for
- Adult patient planned for elective primary laparoscopic sleeve gastrectomy surgery
- Body Mass Index (BMI) ≥ 40 kg/ / m²
- Age ≥ 18
- ASA physical health class II-III.
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Firat University Hospital, Department of Anesthesiology and Reanimation Coordinator of this site? Confirm its status | Elâzığ | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.