NCT06838975Active, not recruiting
Virtual Reality Rehabilitation for Cognitive, Emotional, and Motor Recovery in Neurological Disorders
Effectiveness of Virtual Reality Rehabilitation to Improve Cognitive, Emotional, Relational, and Motor Domains in Patients With Neurological and Neurodegenerative Disorders
Source: ClinicalTrials.gov · Last updated 21 Feb 2025
Brief summary (registry, in English)
This randomized controlled trial (RCT) evaluates the effectiveness of virtual reality (VR) rehabilitation in improving cognitive, emotional, social, and motor functions in patients with neurological disorders (ABI, SCI, MS, PD). It investigates whether VR improves motor and cognitive functions more than traditional therapy, identifies neurophysiological changes (EEG, fNIRS, MRI), and assesses the integration of VR with NIBS or telerehabilitation. Conducted over three years at IRCCS Centro Neurolesi Bonino Pulejo, participants are randomly assigned to either a VR training group or an active control group receiving traditional rehabilitation. Procedures include baseline assessments (T0), 20 rehabilitation sessions over 8 weeks, post-intervention evaluations (T1), and a 3-month follow-up (T2). Primary outcomes measure motor and cognitive function (MoCA, MMSE, FIM, TUG, Berg Balance Scale), neurophysiological changes (EEG, MRI, fNIRS, motion analysis), and emotional/social function (Empathy Quotient, Hamilton Depression Scale).
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 328 (actual)
- First submitted
- 31 Jan 2025
- Start date
- 16 Jan 2025
- Primary completion date
- 29 Sept 2027
- Lead sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
- Diseases
- Parkinson disease, Multiple sclerosis
- NCT number
- NCT06838975
What you commit to
- Study type: Interventional
- Participants enrolled: 328
- From 16 Jan 2025 to the primary completion date, 29 Sept 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindications for MRI (e.g., pacemakers, incompatible implants)
Other illness
- Major psychiatric disorders (e.g., psychosis, severe depression, anxiety disorders)
- Severe medical conditions that impair participation
Other
- Sensory or motor impairments preventing VR interaction
- Pregnancy
Who the study is looking for
- Age: 18 to 75 years
- Diagnosis:
- Parkinson's Disease (PD) (MDS Clinical Diagnostic Criteria) Multiple Sclerosis (MS) (McDonald Criteria) Spinal Cord Injury (SCI) (ASIA Impairment Scale) Acquired Brain Injury (ABI) (WHO Criteria for Stroke)
- Education: Minimum of 5 years of formal education
- Cognitive and physical ability to engage in rehabilitation
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| IRCCS Centro Neurolesi Bonino Pulejo Coordinator of this site? Confirm its status | Messina | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.