NCT06840977Recruiting
COLON ERDERLY LOW DOSE
RETROSPECTIVE OBSERVATIONAL STUDY OF CHEMOTHERAPY IN ELDERLY PATIENTS IN THE FIRST-LINE TREATMENT OF METASTATIC COLORECTAL CANCER
Source: ClinicalTrials.gov · Last updated 16 Jul 2026
Brief summary (registry, in English)
In this retrospective observational study, the case series of patients undergoing first-line treatment for metastatic colorectal adenocarcinoma with doublet fixed-dose and reduced-dose chemotherapy in combination with full-dose monoclonal antibody in patients aged 70 years or older is collected.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 51 (estimated)
- First submitted
- 18 Feb 2025
- Start date
- 7 Jul 2026
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- Matteo Clavarezza
- Diseases
- Colorectal cancer
- NCT number
- NCT06840977
What you commit to
- Study type: Observational
- Planned participants: 51
- From 7 Jul 2026 to the primary completion date, 30 Jun 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients not eligible for doublet chemotherapy by clinical decision
Other
- Patients with MSI tumours
- Patients with BRAF V600E mutated tumours
Who the study is looking for
- Patients with metastatic colorectal adenocarcinoma not treated with any therapy in the metastatic phase. Previous (neo)-adjuvant treatment with fluoroderivatives with or without Oxaliplatin is permitted.
- Age ≥ 70 years
- G8 score ≥ 12
- Patients with colorectal adenocarcinoma MSS
- Patients with BRAF WT colorectal adenocarcinoma
- Ability to understand and sign the informed consent form.
Age in the registry: 70 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| E.O. Ospedali Galliera Coordinator of this site? Confirm its status | Genoa | Italy | Not yet recruiting |
| E.O. Ospedali Galliera Coordinator of this site? Confirm its status | Genova | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.