NCT06841627Completed
Osteopathic Manual Therapy (OMT) and Brain Structure and Function in Primary Headache Patients: A Pilot Study
Exploring the Mechanism of Osteopathic Manual Therapy (OMT) on Brain Structure and Function in Primary Headache Patients: A Pilot Study
Source: ClinicalTrials.gov · Last updated 6 May 2026
Brief summary (registry, in English)
Chronic headaches are associated with changes in brain structure and function that may be associated with increased suffering and disability. Understanding how Osteopathic Manipulative Therapy (OMT) affects these changes would reveal new insight into how the brain processes pain and returns to normal function. Also, demonstrating these changes would provide evidence regarding how OMT causes a reduction in pain and disability, supporting the recommendation for OMT as a primary treatment option for headaches.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 31 (actual)
- First submitted
- 19 Feb 2025
- Start date
- 5 Aug 2025
- Primary completion date
- 1 Oct 2025
- Lead sponsor
- Edward Via Virginia College of Osteopathic Medicine
- Diseases
- Migraine
- NCT number
- NCT06841627
What you commit to
- Study type: Interventional
- Participants enrolled: 31
- From 5 Aug 2025 to the primary completion date, 1 Oct 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- currently undergoing manual therapy type treatment or have a a treatment within 2 weeks of enrollment(chiropractic, OMT, massage, PT)
- have had an injection to treat headaches within the previous 3 months from study enrollment
Other illness
- presence of headaches due to some other underlying medical condition (secondary headaches)
- fibromyalgia, epilepsy
- diagnosis of a neurodegenerative disorder
- history of brain tumor or cancer
- history of cervical radiculopathy (pinched nerve in the neck)
Other
- traumatic brain injury
- currently pregnant
- contraindications to MRI.
Who the study is looking for
- current diagnosis of primary headache (migraine, tension-type, cluster) from a healthcare provider
- have experienced at least one headache episode a month for the previous 1 year (or longer)
- age of PH onset was less than 50 years, currently taking medication for headaches.
Age in the registry: 18 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Auburn University MRI Center and Edward Via College of Medicine Coordinator of this site? Confirm its status | Auburn | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.