NCT06842745RecruitingPhase 2
Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia
Personalized Transcranial Magnetic Stimulation and Constraint Induced Language Therapy to Treat Mild Post-Stroke Aphasia
Source: ClinicalTrials.gov · Last updated 5 Mar 2026
Brief summary (registry, in English)
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke. The main questions this study aims to answer are: 1. Can TMS combined with SLT improve conversational speech and comprehension? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and SLT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat post-stroke mild aphasia. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo a MRI * Participate in 10 consecutive sessions (Monday-Friday) of TMS and SLT treatment * Complete follow-up assessments 2 and 4 months after treatment
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 24 (estimated)
- First submitted
- 18 Feb 2025
- Start date
- 11 Feb 2025
- Primary completion date
- 31 Aug 2026
- Lead sponsor
- University of Pennsylvania
- Diseases
- Stroke
- NCT number
- NCT06842745
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 24
- From 11 Feb 2025 to the primary completion date, 31 Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Other neurological disorders, beside stroke (i.e. dementia, traumatic brain injury, multiple sclerosis)
- Active psychiatric disorders (i.e. bipolar disorder, schizophrenia)
- Pacemaker or cardiac defibrillator
- Epilepsy, or seizure in the past 6 months
Other
- Ongoing substance or alcohol abuse
- Diagnosis of tinnitus
Who the study is looking for
- Left Hemisphere stroke
- Stroke occurred more than 6 months ago
- Mild Aphasia (WAB AQ score \> 85)
- Proficient in English
Age in the registry: 40 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.