Korean Health Screening-Based Metabolic Dysfunction-Associated Steatotic Liver Disease Registry

Brief summary (registry, in English)

The goal of this observational study is to establish a multi-center registry to better understand Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) using health screening data from Korean hospitals. MASLD is a liver condition where excess fat builds up in the liver and is closely linked to metabolic health problems like high blood pressure, diabetes, and obesity. The main questions this study aims to answer are: * What are the characteristics of people with MASLD? * How is MASLD related to other health conditions, especially heart and blood vessel diseases? * What factors might help identify MASLD early? Researchers will compare two groups of people: * People who have MASLD * People who don't have MASLD (control group) This study will look at health screening records from 2020 to 2023 from six Korean hospitals. The research team will collect and analyze: * Basic health information (age, gender, weight, height, waist size) * Lifestyle habits (drinking, smoking, exercise, eating habits) * Medical conditions (high blood pressure, diabetes, high cholesterol) * Results from medical tests including: Liver ultrasound and Fibroscan results Heart CT scans Blood vessel ultrasound Blood test results Other health screening results Participants in this study will not need to do anything new. The researchers will only look at information that was already collected during regular health screenings. All personal information will be protected and kept private. This research could help doctors: * Better understand who is at risk for MASLD * Find MASLD earlier * Develop better ways to prevent and treat MASLD * Understand how MASLD is connected to other health problems The study will take place over 3 years and includes adults age 19 and older who had health screenings at participating Korean hospitals. People who drink large amounts of alcohol or have other liver diseases will not be included in the study. By learning more about MASLD through this registry study, researchers hope to improve healthcare for people with or at risk for this liver condition.

What you commit to

• Study type: Observational
• Planned participants: 6000
• From 1 Mar 2025 to the primary completion date, 1 May 2025
• 5 sites in 1 country
• Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Who the study is looking for

Age in the registry: 19 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (5)

Sites in registry order. Pick your city on the disease page to sort them by distance.

Related publications

• Circulating Estradiol as an Independent Risk Factor for Metabolic Dysfunction-Associated Steatotic Liver Disease and Fibrosis Risk in Women: Evidence From a Multicenter Health-Checkup Cohort.J Korean Med Sci · 2026 · PMID 42978133
• Metabolic Dysfunction-Associated Steatotic Liver Disease and Vascular Complications: Associations with Serum Testosterone Levels in a Korean Multicenter Male Cohort.Gut Liver · 2026 · PMID 42670694