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NCT06844006Active, not recruiting

Investigating the Impact of Nudging Cardiologists to Prescribe Class I Recommendations Foundational- and Additional Medical Therapy in Heart Failure Patients

Assessment of Digital Care on Clinical Impact and Efficiency Using a Stepped Wedge Cluster RCT in Heart Failure Patients: the ADMINISTER II Trial

Source: ClinicalTrials.gov · Last updated 15 Oct 2026

Brief summary (registry, in English)

This study investigates the impact of a nudge-based intervention on improving 2026 European Society of Cardiology guideline class I Foundational Medical Therapy (FMT) and Additional medical therapy (AMT) prescription among cardiologists. Using a stepped wedge randomized controlled trial design, we assess whether digital decision support-leveraging home monitoring and clinical data-enhances adherence to guideline-recommended medication titration. The primary outcomes include HF related hospitalization rates and all cause mortality.

Status (registry)
Active, not recruiting
Study type
Interventional
Enrollment
1320 (actual)
First submitted
19 Feb 2025
Start date
9 Oct 2026
Primary completion date
9 Jan 2028
Lead sponsor
Medisch Spectrum Twente
NCT number
NCT06844006

What you commit to

  • Study type: Interventional
  • Participants enrolled: 1320
  • From 9 Oct 2026 to the primary completion date, 9 Jan 2028
  • 5 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Allergies that make uptitration impossible.
  • Severe psychological disorders.

Other

  • Not understanding the Dutch Language.
  • Admission to hospice or palliative care.

Who the study is looking for

  • All heart failure diagnoses
  • \>18 years

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (5)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
OLVG Oost
Coordinator of this site? Confirm its status
AmsterdamNetherlandsUnknown status
Catharina Ziekenhuis
Coordinator of this site? Confirm its status
EindhovenNetherlandsUnknown status
Medisch Spectrum Twente
Coordinator of this site? Confirm its status
EnschedeNetherlandsUnknown status
St. Antonius Hospital
Coordinator of this site? Confirm its status
NieuwegeinNetherlandsUnknown status
Maasstad Hospital
Coordinator of this site? Confirm its status
RotterdamNetherlandsUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.