NCT06845098Not yet recruiting
Impact of Thyroid Treatment on Ovarian Function and Pregnancy Outcomes in Women with Differentiated Thyroid Cancer
Impact of Thyroid Treatment on Ovarian Function and Pregnancy Outcomes in Women with Differentiated Thyroid Cancer: a Prospective Cohort Study
Source: ClinicalTrials.gov · Last updated 25 Feb 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This project aims to study the effects of different types of thyroid surgery and RAIT on ovarian function and pregnancy outcomes of DTC women of childbearing age, analyze possible risk factors, and assess whether potential risk factors such as age, thyroid stimulating hormone (TSH) levels and positive thyroid antibodies are related to ovarian hypofunction and adverse pregnancy outcomes.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 300 (estimated)
- First submitted
- 10 Feb 2025
- Start date
- 20 Feb 2025
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Zhejiang Provincial People's Hospital
- Diseases
- Thyroid cancer, Ovarian cancer
- NCT number
- NCT06845098
What you commit to
- Study type: Interventional
- Planned participants: 300
- From 20 Feb 2025 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with malignant tumors in other parts or low undifferentiated thyroid cancer;
- History of ovarian surgery, hysterectomy, pelvic surgery or radiation therapy;
- Patients diagnosed with polycystic ovary syndrome by the Rotterdam standard;
- Patients with ovarian failure;
- Patients have infectious factors, immune diseases and metabolic diseases that may affect pregnancy outcomes;
- Pregnancy contraindications or diseases that have a clear impact on pregnancy.
Other
- Patients with abnormal liver and kidney function;
- TNM stage II and above;
- Pregnancy;
- Have the following uterine abnormalities, such as uterine malformation (single-horned uterus, double uterus); untreated mediastinal uterus, submucosal uterine fibroids, multiple endometrial polyps, or severe uterine adhesion.
Who the study is looking for
- Age 20-45 years old;
- Premenopausal women whose thyroid B-ultrasound + surgical pathology is clearly differentiated thyroid cancer (papillar thyroid cancer or follicular thyroid cancer);
- TNM stage is in stage I (T1-3, N0 or N1, M0);
- Treatment of thyroid tumor resection: unilateral lobe of the thyroid + isthmus resection, total thyroidectomy, total thyroidectomy + RAIT.
Age in the registry: 20 years to 45 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Zhejiang Provincial People's Hospital Coordinator of this site? Confirm its status | Hangzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.