NCT06846541RecruitingPhase 3
An Extension Study to Evaluate Safety, Efficacy, and Durability of Response to ESK-001 for Moderate to Severe Plaque Psoriasis (ONWARD3)
An Extension Study in Patients with Moderate to Severe Plaque Psoriasis to Evaluate the Long-term Safety, Efficacy and Durability of Response to ESK-001 (ONWARD3)
Source: EU CTIS (euclinicaltrials.eu) · Last updated 16 Sept 2026
Brief summary (registry, in English)
To assess the long-term safety and tolerability of ESK-001 in patients with moderate to severe plaque psoriasis
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 931 (estimated)
- First submitted
- 20 Dec 2024
- Start date
- 13 Jun 2025
- Lead sponsor
- Alumis Inc.
- Diseases
- Psoriasis
- NCT number
- NCT06846541
- EU CT number
- 2024-511166-36-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 931
- 123 sites in 13 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study, not your situation.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any acute or chronic illness/condition or evidence of an unstable clinical condition that, in the opinion of the Investigator, will substantially increase the risk to the patient if they continue to receive ESK-001 treatment in this extension study
Other
- Pregnant, lactating, or planning to get pregnant during the study
- Deemed by the Investigator to be inappropriate for the study or unable to comply with the protocol
Who the study is looking for
- Males or females, age ≥18 years
- Completed either of the two previous (parent) studies of ESK-001 in moderate to severe plaque psoriasis
- ESK-001 safety and tolerability were acceptable in the parent study
- Women of childbearing potential (WOCBP) and males who are sexually active with WOCBP must agree to adhere to a highly effective method of contraception for the entirety of the study
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (123)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Klinik Hietzing Coordinator of this site? Confirm its status | Vienna | Austria | Completed |
| Centre Hospitalier Universitaire de Liège Coordinator of this site? Confirm its status | Liège | Belgium | Completed |
| Cliniques Universitaires Saint-Luc Coordinator of this site? Confirm its status | Sint-Lambrechts-Woluwe | Belgium | Completed |
| Multiprofile Hospital For Active Treatment "Dr. Tota Venkova" AD Coordinator of this site? Confirm its status | Gabrovo | Bulgaria | Active, not recruiting |
| Medical Center Kordis OOD Coordinator of this site? Confirm its status | Pleven | Bulgaria | Active, not recruiting |
| Centar Za Kojno-Venericheski Zabolyavania EOOD Coordinator of this site? Confirm its status | Sofia | Bulgaria | Active, not recruiting |
| Alexandrovska University Hospital Coordinator of this site? Confirm its status | Sofia | Bulgaria | Active, not recruiting |
| Diagnostic-Consultative Center Alexandrovska EOOD Coordinator of this site? Confirm its status | Sofiya | Bulgaria | Active, not recruiting |
| Pratia Brno s.r.o. Coordinator of this site? Confirm its status | Brno-Stred | Czechia | Active, not recruiting |
| Kozni ambulance Kutna Hora, s.r.o. Coordinator of this site? Confirm its status | Kutná Hora | Czechia | Active, not recruiting |
| Vesalion s.r.o. Coordinator of this site? Confirm its status | Moravska Ostrava A Privoz | Czechia | Active, not recruiting |
| CCR Ostrava s.r.o. Coordinator of this site? Confirm its status | Moravska Ostrava A Privoz | Czechia | Active, not recruiting |
| DERMAMEDICA, s.r.o. Coordinator of this site? Confirm its status | Náchod | Czechia | Active, not recruiting |
| Nemocnice AGEL Nový Jičín a.s. Coordinator of this site? Confirm its status | Nový Jičín | Czechia | Active, not recruiting |
| Pratia Pardubice a.s. Coordinator of this site? Confirm its status | Pardubice I | Czechia | Active, not recruiting |
| Fakultni Nemocnice Plzen Coordinator of this site? Confirm its status | Plzen 3 | Czechia | Active, not recruiting |
| Dermskin s.r.o. Coordinator of this site? Confirm its status | Povel | Czechia | Active, not recruiting |
| Fakultni nemocnice Kralovske Vinohrady Coordinator of this site? Confirm its status | Prague | Czechia | Active, not recruiting |
| Praglandia s.r.o. Coordinator of this site? Confirm its status | Prague | Czechia | Active, not recruiting |
| Clintrial s.r.o. Coordinator of this site? Confirm its status | Prague 10 | Czechia | Active, not recruiting |
| Pratia Prague s.r.o. Coordinator of this site? Confirm its status | Prague 3 | Czechia | Active, not recruiting |
| Sanatorium profesora Arenbergera Coordinator of this site? Confirm its status | Praha | Czechia | Active, not recruiting |
| Dermatologická Ambulance Coordinator of this site? Confirm its status | Svitavy | Czechia | Active, not recruiting |
| Privat Practice Dr. V. Mihaescu Coordinator of this site? Confirm its status | Augsburg | Germany | Active, not recruiting |
| Thermalsole und Schwefelbad Bentheim GmbH Coordinator of this site? Confirm its status | Bad Bentheim | Germany | Active, not recruiting |
| ISA - Interdisciplinary Study Association GmbH Coordinator of this site? Confirm its status | Berlin | Germany | Active, not recruiting |
| Klinikum Bielefeld gGmbH Coordinator of this site? Confirm its status | Bielefeld | Germany | Active, not recruiting |
| Fachaerztliche Gemeinschaftspraxis fuer Dermatologie Und Venerologie Allergologie Umweltmedizin Lasermedizin GbR Coordinator of this site? Confirm its status | Blankenfelde-Mahlow | Germany | Active, not recruiting |
| Dr. Niesmann And Dr. Othlinghaus GbR Coordinator of this site? Confirm its status | Bochum | Germany | Active, not recruiting |
| Hautarztpraxis an der Hase Coordinator of this site? Confirm its status | Bramsche | Germany | Active, not recruiting |
| Rosenpark Research Gmbh Coordinator of this site? Confirm its status | Darmstadt | Germany | Active, not recruiting |
| Klinische Forschung Dresden GmbH Coordinator of this site? Confirm its status | Dresden | Germany | Active, not recruiting |
| Hautarztpraxis Dr.Gerlach Coordinator of this site? Confirm its status | Dresden | Germany | Active, not recruiting |
| Universitaetsklinikum Erlangen AöR Coordinator of this site? Confirm its status | Erlangen | Germany | Active, not recruiting |
| Goethe University Frankfurt Coordinator of this site? Confirm its status | Frankfurt Am Main | Germany | Active, not recruiting |
| Universitaetsklinikum Schleswig-Holstein AöR Coordinator of this site? Confirm its status | Kiel | Germany | Active, not recruiting |
| Medizinisches Versorgungszentrum DermaKiel GmbH Coordinator of this site? Confirm its status | Kiel | Germany | Active, not recruiting |
| Universitaetsklinikum Schleswig-Holstein AöR Coordinator of this site? Confirm its status | Luebeck | Germany | Active, not recruiting |
| Magdeburger Company For Medical Studies & Services GmbH Coordinator of this site? Confirm its status | Magdeburg | Germany | Active, not recruiting |
| BAG Dres. med. Quist PartG Coordinator of this site? Confirm its status | Mainz | Germany | Active, not recruiting |
| Universitaet Muenster Coordinator of this site? Confirm its status | Muenster | Germany | Active, not recruiting |
| Klinikum Oldenburg Aor Coordinator of this site? Confirm its status | Oldenburg | Germany | Active, not recruiting |
| Klinische Forschung Osnabrueck Coordinator of this site? Confirm its status | Osnabrueck | Germany | Active, not recruiting |
| Hautarztpraxis Mortazawi GbR Coordinator of this site? Confirm its status | Remscheid | Germany | Active, not recruiting |
| Klinische Forschung Schwerin GmbH Coordinator of this site? Confirm its status | Schwerin | Germany | Active, not recruiting |
| Universitaetsklinikum Tuebingen AöR Coordinator of this site? Confirm its status | Tuebingen | Germany | Active, not recruiting |
| Innomedica OÜ Coordinator of this site? Confirm its status | Tallinn | Estonia | Active, not recruiting |
| Center for Clinical and Basic Research AS Coordinator of this site? Confirm its status | Tallinn | Estonia | Active, not recruiting |
| Tartu University Hospital Coordinator of this site? Confirm its status | Tartu Linn | Estonia | Active, not recruiting |
| Kliiniliste Uuringute Keskus OÜ Coordinator of this site? Confirm its status | Tartu Linn | Estonia | Active, not recruiting |
| Hospital General Universitario Dr. Balmis Coordinator of this site? Confirm its status | Alicante | Spain | Active, not recruiting |
| Hospital Germans Trias i Pujol Coordinator of this site? Confirm its status | Badalona | Spain | Active, not recruiting |
| Hospital del Mar Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Hospital de la Santa Creu i Sant Pau Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Hospital Universitario La Paz Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Hospital de Manises Coordinator of this site? Confirm its status | Manises | Spain | Active, not recruiting |
| Complexo Hospitalario Universitario De Santiago Coordinator of this site? Confirm its status | Santiago de Compostela | Spain | Active, not recruiting |
| Tagast 41 Coordinator of this site? Confirm its status | Nice | France | Active, not recruiting |
| Centre Hospitalier Universitaire Rouen Coordinator of this site? Confirm its status | Rouen | France | Active, not recruiting |
| Uno Medical Trials Kft. Coordinator of this site? Confirm its status | Budapest XV | Hungary | Active, not recruiting |
| Orvostudomanyi Kutato es Fejleszto Kft Coordinator of this site? Confirm its status | Debrecen | Hungary | Active, not recruiting |
| Derma-B Kft. Coordinator of this site? Confirm its status | Debrecen | Hungary | Active, not recruiting |
| University of Debrecen Coordinator of this site? Confirm its status | Debrecen | Hungary | Active, not recruiting |
| Bacs-Kiskun Varmegyei Oktatokorhaz Coordinator of this site? Confirm its status | Kecskemét | Hungary | Active, not recruiting |
| Dermamed Research Kft. Coordinator of this site? Confirm its status | Orosháza | Hungary | Active, not recruiting |
| Allergo-Derm Bakos Kft Coordinator of this site? Confirm its status | Szolnok | Hungary | Active, not recruiting |
| Medmare Bt. Coordinator of this site? Confirm its status | Veszprém | Hungary | Active, not recruiting |
| Semigallia SIA Coordinator of this site? Confirm its status | Kuldiga | Latvia | Active, not recruiting |
| Veselibas Centrs 4 SIA Coordinator of this site? Confirm its status | Riga | Latvia | Active, not recruiting |
| Veseliba un estetika SIA Coordinator of this site? Confirm its status | Riga | Latvia | Active, not recruiting |
| Rigas 1. slimnica SIA Coordinator of this site? Confirm its status | Riga | Latvia | Active, not recruiting |
| J.Kisis SIA Coordinator of this site? Confirm its status | Riga | Latvia | Active, not recruiting |
| Smite Aija practice in Dermatology Coordinator of this site? Confirm its status | Talsi | Latvia | Active, not recruiting |
| Clinicmed Daniluk Nowak Sp. k. Coordinator of this site? Confirm its status | Bialystok | Poland | Active, not recruiting |
| Specderm Poznanska sp.j. Coordinator of this site? Confirm its status | Bialystok | Poland | Active, not recruiting |
| Pratia S.A. Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Active, not recruiting |
| Centrum Medyczne Dr Rajzer Sp. z o.o. Coordinator of this site? Confirm its status | Cracow | Poland | Active, not recruiting |
| Pratia S.A. Coordinator of this site? Confirm its status | Cracow | Poland | Active, not recruiting |
| Krakowskie Centrum Medyczne Sp. z o.o. Coordinator of this site? Confirm its status | Cracow | Poland | Active, not recruiting |
| Centrum Medyczne All-Med Badania Kliniczne Coordinator of this site? Confirm its status | Cracow | Poland | Active, not recruiting |
| Synexus Polska Sp z o.o. Coordinator of this site? Confirm its status | Gdansk | Poland | Active, not recruiting |
| Centrum Badan Klinicznych PI-House sp. z o.o. Coordinator of this site? Confirm its status | Gdansk | Poland | Active, not recruiting |
| Synexus Polska Sp. z o.o. Coordinator of this site? Confirm its status | Gdynia | Poland | Active, not recruiting |
| Pratia S.A. Coordinator of this site? Confirm its status | Gdynia | Poland | Active, not recruiting |
| Waldemar Placek DERM-ART Szkoleniowo.Naukowy i Naukowo-Badawczy Ośrodek Coordinator of this site? Confirm its status | Gdynia | Poland | Active, not recruiting |
| Pratia S.A. Coordinator of this site? Confirm its status | Katowice | Poland | Active, not recruiting |
| Provita Sp z o o Coordinator of this site? Confirm its status | Katowice | Poland | Active, not recruiting |
| Care Clinic Sp. Z O.O. Coordinator of this site? Confirm its status | Katowice | Poland | Active, not recruiting |
| Vita Longa Sp. Z o.o. Coordinator of this site? Confirm its status | Katowice | Poland | Active, not recruiting |
| Diamond Clinic Sp. z o.o., Diamond Medical Center Coordinator of this site? Confirm its status | Krakow | Poland | Active, not recruiting |
| Futuremeds Sp. z o.o. Coordinator of this site? Confirm its status | Lodz | Poland | Active, not recruiting |
| Dermoklinika Centrum Medyczne s.c. M. Kierstan, J. Narbutt, A. Lesiak Coordinator of this site? Confirm its status | Łódź | Poland | Active, not recruiting |
| Luxderm Specjalistyczny Gabinet Dermatologiczny Prof. Dr. Hab. N. Med. Dorota Krasowska Coordinator of this site? Confirm its status | Lublin | Poland | Active, not recruiting |
| Zanamed Medical Clinic Sp. z o.o. Coordinator of this site? Confirm its status | Lublin | Poland | Active, not recruiting |
| Uniwersytecki Szpital Kliniczny Im. Fryderyka Chopina W Rzeszowie Coordinator of this site? Confirm its status | Rzeszów | Poland | Active, not recruiting |
| Velocity Nova Sp. z o.o. Coordinator of this site? Confirm its status | Skierniewice | Poland | Active, not recruiting |
| RCMed Oddzial Sochaczew Coordinator of this site? Confirm its status | Sochaczew | Poland | Active, not recruiting |
| LASER CLINIC s.c. dr T. Kochanowski dr A. Królicki Coordinator of this site? Confirm its status | Szczecin | Poland | Active, not recruiting |
| Futuremeds Sp. z o.o. Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| Evimed Sp. z o.o. Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| MTZ Clinical Research powered by Pratia Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| Medicover Integrated Clinical Services Sp. z o.o. Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| Klinika Reuma Park Sp. z o.o. S.K. Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| Klinika Ambroziak Sp. z o.o. Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| Royalderm Agnieszka Nawrocka Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| Clinical Best Solutions Sp. z o.o. S.K. Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| Dorota Bystrzanowska High-Med. Przychodnia Specjalistyczna Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| Rheuma Medicus Sp z o o Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| Synexus Polska Sp. z o.o. Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| WroMedica I Bielicka A Strzalkowska s c Coordinator of this site? Confirm its status | Wroclaw | Poland | Active, not recruiting |
| dermMedica Sp. z o.o Coordinator of this site? Confirm its status | Wroclaw | Poland | Active, not recruiting |
| Synexus Polska Sp. z o.o. Coordinator of this site? Confirm its status | Wroclaw | Poland | Active, not recruiting |
| Unidade Local De Saude Do Alto Ave E.P.E. Coordinator of this site? Confirm its status | Guimaraes | Portugal | Active, not recruiting |
| Hospital Cuf Descobertas S.A. Coordinator of this site? Confirm its status | Lisbon | Portugal | Active, not recruiting |
| Unidade Local De Saude De Santo Antonio E.P.E. Coordinator of this site? Confirm its status | Porto | Portugal | Active, not recruiting |
| Centrul Medical De Diagnostic Si Tratament Ambulator Neomed S.R.L. Coordinator of this site? Confirm its status | Brasov | Romania | Completed |
| Bio Terra Med S.R.L Coordinator of this site? Confirm its status | Bucharest | Romania | Completed |
| Cabinet Medical de Dermatovenerologie Prof. Dr. Orasan Remus Ioan Coordinator of this site? Confirm its status | Cluj | Romania | Completed |
| Policlinica Centrala Craiova (Regina Maria) Coordinator of this site? Confirm its status | Craiova | Romania | Completed |
| Centrul Medical Dr. Ianosi Coordinator of this site? Confirm its status | Craiova | Romania | Completed |
| Vitaplus Medclin S.R.L. Coordinator of this site? Confirm its status | Craiova | Romania | Completed |
| Cabinet Dermatologie Lauderma Coordinator of this site? Confirm its status | Iași | Romania | Completed |
| Spitalul Clinic Judeţean Mureş Coordinator of this site? Confirm its status | Târgu Mureş | Romania | Completed |
This page is information, not medical advice. Discuss any trial with your doctor.