Evaluate the Safety and Pharmacokinetics/Pharmacodynamics of HS-20118

Prior treatment

• History of drug abuse within the past 5 years or use of illicit drugs within 3 months before the study; or positive for urine drug screening;
  • For the MAD study:
• Current use of illicit drugs or prior use of illicit drugs within the specific time periods;
• Known history of recurrent or chronic infections, or prior history of chronic or recurrent infections, including but not limited to: chronic renal infection, chronic chest infection (e.g., bronchiectasis), symptomatic urinary tract infection, and open, draining, or infected skin wounds; history of serious infections (e.g., sepsis, pneumonia, and pyelonephritis), or hospitalization or treatment with intravenous antibiotics for infections within 2 months before screening;

Other illness

• Participants with immune-related diseases and medical history at screening;
• Participants with a history of drug or other allergies who are considered by the investigator to be at high risk for participating in this study, or who may be allergic to the investigational medicinal product or any component of the investigational medicinal product as judged by the investigator;
• Guttate psoriasis, pustular psoriasis, erythrodermic psoriasis, drug-induced psoriasis, or other diseases that affect the treatment results;

Other

• For the SAD study:

• For the SAD study:
• Healthy adults aged 18-45 years (inclusive) at the time of signing the informed consent form;
• Male participants weighing ≥ 50 kg and female participants weighing ≥ 45 kg, both ≤ 110 kg; body mass index (weight/square of height (kg/m2)) within the range of 18-28 kg/m2 (inclusive);
• Normal results or abnormal results but without clinical significance in comprehensive examinations, including general physical examination, vital signs, laboratory tests, 12-lead ECG, abdominal color Doppler ultrasound, and chest X-ray from the frontal and lateral position ;
  • For the MAD study:
• Male or female participants aged 18-65 years (inclusive) at the time of signing the informed consent form;
• Male participants weighing ≥ 50 kg and female participants weighing ≥ 45 kg, both ≤ 110 kg;
• Chronic plaque psoriasis for at least 6 months with or without psoriatic arthritis;