NCT06849011Not yet recruiting
Inflammatory and Metabolic Prognostic Assessment in Critically Ill Neurological Patients
Development and Validation of a Prognostic Prediction Model for Adverse Outcomes in Neurocritical Patients Receiving Enteral Nutrition Based on Key Inflammatory and Metabolic Markers
Source: ClinicalTrials.gov · Last updated 27 Feb 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The study aims to develop and validate a prognostic prediction model for adverse outcomes in neurocritical patients receiving enteral nutrition based on key inflammatory and metabolic markers. This model will serve as a clinical tool to help physicians identify high-risk patients and guide individualized nutritional support strategies.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 1185 (estimated)
- First submitted
- 12 Feb 2025
- Start date
- 1 Mar 2025
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Yan Zhang
- Diseases
- Stroke
- NCT number
- NCT06849011
What you commit to
- Study type: Observational
- Planned participants: 1185
- From 1 Mar 2025 to the primary completion date, 31 Dec 2026
- 19 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Severe malnutrition prior to admission, defined as BMI \< 16 kg/m².
- Receiving hypothermia treatment or core body temperature \< 36°C.
Other illness
- End-stage disease with an expected survival time of \< 48 hours, or severe dysfunction of the heart, lungs, or other vital organs, leading to hemodynamic instability.
- Malignant tumors.
Other
- Pregnant or lactating women.
Who the study is looking for
- Age between 18 and 80 years, no gender restrictions.
- Within 7 days of disease onset and expected NICU stay of at least 7 days.
- Eligible for enrollment within 24 hours of NICU admission, with enteral nutrition (EN) initiated and continued for at least 7 days.
- Non-traumatic severe brain injury patients (including cerebrovascular disease and encephalitis) with a Glasgow Coma Scale (GCS) score ≤12.
- NRS 2002 score ≥3.
- Kuwata drinking test ≥ grade 3.
- Acute Gastrointestinal Injury (AGI) grade 1 or 2.
- Signed informed consent obtained from the patient or their legal representative.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (19)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Xuanwu Hospital, Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| The Ninth Medical Center of Chinese PLA General Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Beijing Hui People's Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| You'anmen Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Chifeng Municipal Hospital Coordinator of this site? Confirm its status | Chifeng | China | Unknown status |
| Guizhou Provincial People's Hospital Coordinator of this site? Confirm its status | Guiyang | China | Unknown status |
| Inner Mongolia Autonomous Region People's Hospital Coordinator of this site? Confirm its status | Hohhot | China | Unknown status |
| The First Hospital of Jilin University Coordinator of this site? Confirm its status | Jilin City | China | Unknown status |
| Qilu Hospital of Shandong University Coordinator of this site? Confirm its status | Jinan | China | Unknown status |
| The 960th Hospital of Joint Logistics Support Force of Chinese PLA Coordinator of this site? Confirm its status | Jinan | China | Unknown status |
| The First People's Hospital of Yunnan Province Coordinator of this site? Confirm its status | Kunming | China | Unknown status |
| The 940th Hospital of Joint Logistics Support Force of Chinese PLA Coordinator of this site? Confirm its status | Lanzhou | China | Unknown status |
| Liaocheng People's Hospital Coordinator of this site? Confirm its status | Liaocheng | China | Unknown status |
| The First Hospital of Hebei Medical University Coordinator of this site? Confirm its status | Shijiazhuang | China | Unknown status |
| The Second Affiliated Hospital of Suzhou University Coordinator of this site? Confirm its status | Suzhou | China | Unknown status |
| The Second Hospital of Shanxi Medical University Coordinator of this site? Confirm its status | Taiyuan | China | Unknown status |
| Tangshan People's Hospital Coordinator of this site? Confirm its status | Tangshan | China | Unknown status |
| General Hospital of Ningxia Medical University Coordinator of this site? Confirm its status | Yinchuan | China | Unknown status |
| Affiliated Hospital of Zunyi Medical University Coordinator of this site? Confirm its status | Zunyi | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.