NCT06849050Completed
The Influence of Acute Continuous Exercise and Adiposity on Appetite Hormones and Neural Correlates of Visual Food Cues
Source: ClinicalTrials.gov · Last updated 10 Sept 2025
Brief summary (registry, in English)
Exercise increases energy expenditure and impacts appetite and energy intake. Some appetite-related hormones such as oxyntomodulin suppress appetite whilst other hormones such as ghrelin stimulate appetite. This study will investigate whether acute continuous walking/jogging influences these hormone concentrations, and whether exercise-induced changes in the hormones correlate with perceptions of appetite, nutritional intake and brain activity in individuals varying in weight status.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 40 (actual)
- First submitted
- 18 Feb 2025
- Start date
- 5 Jul 2024
- Primary completion date
- 3 Sept 2025
- Lead sponsor
- Loughborough University
- Diseases
- Obesity
- NCT number
- NCT06849050
What you commit to
- Study type: Interventional
- Participants enrolled: 40
- From 5 Jul 2024 to the primary completion date, 3 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking any medication which may affect the study outcomes (e.g. liraglutide, semaglutide, insulin, steroids, anti-psychotics)
- Previous bariatric surgery (e.g. gastric bypass, gastric band, sleeve gastrectomy)
Other illness
- Known medical conditions (e.g. diabetes, heart condition)
- Clinically diagnosed eating disorder
- Food allergies or intolerances, or severe dislikes to study foods
Other
- Smokers (vaping is considered smoking in this study)
- Pregnant or breastfeeding
- Have recently donated blood (within eight weeks of visits 2 and 3).
Who the study is looking for
- Body mass index (BMI) between 18.5 - 24.9 kg/m2 and a waist circumference of ≤ 88 cm for women, and ≤ 102 cm for men or a BMI between 25 - 40 kg/m2 and a waist circumference of \> 88 cm for women, and \> 102 cm for men. BMI and waist circumference thresholds vary amongst ethnicities. People with a South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean family background are prone to central adiposity and their cardiometabolic risk occurs at a lower BMI. Therefore, the following BMI and waist circumference thresholds will be applied for people of South Asian, other Asian, Black African and African-Caribbean ethnicity: (1) BMI 18.5 kg/m2 to 23 kg/m2 and waist circumference of \< 90 cm for men and \< 80 cm for women; (2) BMI 23.1 kg/m2 to 40 kg/m2 and waist circumference of ≥ 90 cm for men and ≥ 80 cm for women.
- Normally consumes three meals a day
- Able to walk continuously for 1 hour on a treadmill
- Weight stable for 3 months (\< 3kg change in weight)
- Regular menstrual cycle for the last 6 months (people taking the combined contraceptive pill are eligible for the study)
- Able to undergo a 45-minute MRI scan
Age in the registry: 18 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Loughborough University Coordinator of this site? Confirm its status | Loughborough | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.