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NCT06854458Recruiting

The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study

The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States (SPINS2) Study

Source: ClinicalTrials.gov · Last updated 1 Sept 2026

Brief summary (registry, in English)

This research aims to investigate whether symptoms of chest pain or shortness of breath among the study population are arising due to a heart problem, particularly any reduction of blood flow to the heart muscle from blockages in the coronary blood vessels or inflammation of the heart using cardiac magnetic resonance imaging that measures the amount of blood flow during a stress state meant to simulate vigorous exercise. At present, doctors use standard magnetic resonance imaging pictures of blood flow patterns to treat heart disease. The investigators want to study if detailed blood flow measurements, in addition to the standard blood flow pattern, could diagnose heart disease more accurately and allow more doctors to understand the severity of heart disease. Early research has demonstrated that detailed blood flow measurements may be more accurate in diagnosing heart disease in some patients, but doctors need more information to know how to use these measurements.

Status (registry)
Recruiting
Study type
Interventional
Enrollment
1000 (estimated)
First submitted
24 Feb 2025
Start date
27 Jun 2025
Primary completion date
Jan 2029
Lead sponsor
Brigham and Women's Hospital
NCT number
NCT06854458

What you commit to

  • Study type: Interventional
  • Planned participants: 1000
  • From 27 Jun 2025 to the primary completion date, Jan 2029
  • 13 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Acute myocardial infarction within the past 30 days prior to cardiac magnetic resonance imaging

Other illness

  • metallic device with a high likelihood of non-diagnostic cardiac magnetic resonance images

Lab values

  • Confirmed diagnosis of any significant non-coronary cardiac conditions below:
    • any severe-grade valvular heart disease,
    • left ventricular ejection fraction \<40% from any known non-coronary causes,
    • infiltrative cardiomyopathy,
    • hypertrophic cardiomyopathy,
    • pericardial disease with significant constriction, or

Age

  • any competing conditions leading to an expected survival of \< 2 years

Other

  • active pregnancy,
  • contraindication to vasodilator (regadenoson or adenosine)
  • metallic device or object that poses an magnetic resonance imaging safety hazard

Who the study is looking for

  • male or female at age 35-85 years,
  • presence of either of the following sign/symptom that led to a referral to stress cardiac magnetic resonance imaging:
    • chest pain or anginal equivalent, or
    • abnormal electrocardiogram with a suspicion of coronary artery disease
  • Intermediate or high risk of significant coronary disease based on at least 1 of the following conditions:
    • patient age \> 45 for male, 50 for female b) Diabetes, hypertension, or hypercholesterolemia: by either history or medical treatment c) family history of premature coronary disease: first degree relative at age \<= 55 male and \<=65 female d) history of smoking of \> 10 packed-years e) post-menopausal state \>5 years f) any chronic inflammatory conditions d) Body mass index \> 30 e) Any medical documentation of coronary or peripheral artery disease

Age in the registry: 35 years to 85 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (13)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Brigham and Women's Hospital
Coordinator of this site? Confirm its status
BostonUnited StatesRecruiting
Beth Israel Deaconess Medical Center
Coordinator of this site? Confirm its status
BostonUnited StatesRecruiting
Atrium Health - Sanger Heart & Vascular Institute
Coordinator of this site? Confirm its status
CharlotteUnited StatesRecruiting
University of Virginia
Coordinator of this site? Confirm its status
CharlottesvilleUnited StatesRecruiting
Cleveland Clinic
Coordinator of this site? Confirm its status
ClevelandUnited StatesRecruiting
The Ohio State University
Coordinator of this site? Confirm its status
ColumbusUnited StatesRecruiting
Houston Methodist Hospital
Coordinator of this site? Confirm its status
HoustonUnited StatesRecruiting
UofL Health - Heart Hospital
Coordinator of this site? Confirm its status
LouisvilleUnited StatesRecruiting
Vanderbilt University Medical Center
Coordinator of this site? Confirm its status
NashvilleUnited StatesRecruiting
Virginia Commonwealth University
Coordinator of this site? Confirm its status
RichmondUnited StatesRecruiting
St. Francis Hospital and Heart Center
Coordinator of this site? Confirm its status
RoslynUnited StatesRecruiting
University of Utah
Coordinator of this site? Confirm its status
Salt Lake CityUnited StatesRecruiting
University of California San Francisco
Coordinator of this site? Confirm its status
San FranciscoUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.