NCT06854458Recruiting
The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study
The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States (SPINS2) Study
Source: ClinicalTrials.gov · Last updated 1 Sept 2026
Brief summary (registry, in English)
This research aims to investigate whether symptoms of chest pain or shortness of breath among the study population are arising due to a heart problem, particularly any reduction of blood flow to the heart muscle from blockages in the coronary blood vessels or inflammation of the heart using cardiac magnetic resonance imaging that measures the amount of blood flow during a stress state meant to simulate vigorous exercise. At present, doctors use standard magnetic resonance imaging pictures of blood flow patterns to treat heart disease. The investigators want to study if detailed blood flow measurements, in addition to the standard blood flow pattern, could diagnose heart disease more accurately and allow more doctors to understand the severity of heart disease. Early research has demonstrated that detailed blood flow measurements may be more accurate in diagnosing heart disease in some patients, but doctors need more information to know how to use these measurements.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1000 (estimated)
- First submitted
- 24 Feb 2025
- Start date
- 27 Jun 2025
- Primary completion date
- Jan 2029
- Lead sponsor
- Brigham and Women's Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT06854458
What you commit to
- Study type: Interventional
- Planned participants: 1000
- From 27 Jun 2025 to the primary completion date, Jan 2029
- 13 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Acute myocardial infarction within the past 30 days prior to cardiac magnetic resonance imaging
Other illness
- metallic device with a high likelihood of non-diagnostic cardiac magnetic resonance images
Lab values
- Confirmed diagnosis of any significant non-coronary cardiac conditions below:
- any severe-grade valvular heart disease,
- left ventricular ejection fraction \<40% from any known non-coronary causes,
- infiltrative cardiomyopathy,
- hypertrophic cardiomyopathy,
- pericardial disease with significant constriction, or
Age
- any competing conditions leading to an expected survival of \< 2 years
Other
- active pregnancy,
- contraindication to vasodilator (regadenoson or adenosine)
- metallic device or object that poses an magnetic resonance imaging safety hazard
Who the study is looking for
- male or female at age 35-85 years,
- presence of either of the following sign/symptom that led to a referral to stress cardiac magnetic resonance imaging:
- chest pain or anginal equivalent, or
- abnormal electrocardiogram with a suspicion of coronary artery disease
- Intermediate or high risk of significant coronary disease based on at least 1 of the following conditions:
- patient age \> 45 for male, 50 for female b) Diabetes, hypertension, or hypercholesterolemia: by either history or medical treatment c) family history of premature coronary disease: first degree relative at age \<= 55 male and \<=65 female d) history of smoking of \> 10 packed-years e) post-menopausal state \>5 years f) any chronic inflammatory conditions d) Body mass index \> 30 e) Any medical documentation of coronary or peripheral artery disease
Age in the registry: 35 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (13)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Brigham and Women's Hospital Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
| Beth Israel Deaconess Medical Center Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
| Atrium Health - Sanger Heart & Vascular Institute Coordinator of this site? Confirm its status | Charlotte | United States | Recruiting |
| University of Virginia Coordinator of this site? Confirm its status | Charlottesville | United States | Recruiting |
| Cleveland Clinic Coordinator of this site? Confirm its status | Cleveland | United States | Recruiting |
| The Ohio State University Coordinator of this site? Confirm its status | Columbus | United States | Recruiting |
| Houston Methodist Hospital Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| UofL Health - Heart Hospital Coordinator of this site? Confirm its status | Louisville | United States | Recruiting |
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Recruiting |
| Virginia Commonwealth University Coordinator of this site? Confirm its status | Richmond | United States | Recruiting |
| St. Francis Hospital and Heart Center Coordinator of this site? Confirm its status | Roslyn | United States | Recruiting |
| University of Utah Coordinator of this site? Confirm its status | Salt Lake City | United States | Recruiting |
| University of California San Francisco Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.