NCT06854861TerminatedPhase 1/2
Premixed Glucagon/Insulin Solution for Faster Insulin Absorption in Type 1 Diabetes
Source: ClinicalTrials.gov · Last updated 19 Oct 2026
Brief summary (registry, in English)
We will investigate if Lyumjev premixed with nanogram amounts of glucagon speed up the absorption of insulin and the effect on whole body glucose consumption compared to native lyumjev in patients with type 1 diabetes. To do that we will perform euglycemic clamps investigations in patients meetinng fasting in the morning on two separate days.Frequent samples for glucose and insulin measuremenst will be drawn and the day with lyumjev only will be compared to the day with premixed Lyumjev.
- Status (registry)
- Terminated
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 9 (actual)
- First submitted
- 25 Feb 2025
- Start date
- 1 Apr 2025
- Primary completion date
- 26 Feb 2026
- Lead sponsor
- St. Olavs Hospital
- Diseases
- Type 1 diabetes
- NCT number
- NCT06854861
- EU CT number
- 2023-510408-32-02
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any chronic disease, including psychiatric illnesses, judged incompatible with participation in the study.
- Known hypersensitivity to glucagon or to any of the excipients of the drug formulations.
Other
- Pregnant women or women trying to conceive (women will not be screened by a pregnancy test).
- Unfit for participation for any reason as judged by the investigators.
- Known phaeochromocytoma.
Who the study is looking for
- T1D for at least one year.
- Age 18 - 70 years.
- Last known HbA1c <75 mmol/mol (< 9.0%).
- Treated with an insulin pump or a hybrid artificial pancreas (AP).
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St. Olavs University Hospital Coordinator of this site? Confirm its status | Trondheim | Norway | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.