Qingre Huatan Formula for the Prevention of Early Neurological Deterioration in Acute Ischemic Stroke

Prior treatment

• Received or planned thrombolysis or endovascular therapy after onset.

Other illness

• Suspected secondary stroke caused by brain tumor, brain trauma, hemopathy, etc.
• Already dependent in activities of daily living before the present acute stroke (defined as modified Rankin Scare score ≥2 )
• Diseases that cause motor dysfunction, including osteoarthritis, etc.
• Known severe aphasia or mental illness affecting clinical information collection and evaluation.

Lab values

• Known severe liver or kidney dysfunction (alanine aminotransferase or aspartate transaminase \> 2 times the upper limit of normal value, serum creatinine \> 1.5 times the upper limit of normal value)

Other

• Pregnancy, potential pregnancy or breastfeeding.
• Currently participating in other clinical trials.

• Inpatients diagnosed with acute ischemic stroke. Inpatients diagnosed of acute ischemic stroke.
• Meet the criteria of TCM phlegm-heat syndrome
• Patients at high-risk of END : Magnetic resonance imaging (MRI) reveals new ischemic lesions, with DWI-ASPECTS score ≤ 7, or presence of at least two risk factors of END.
• Acute ischemic stroke within 48 hours after onset.
• Aged 18-80 years, male or female.
• The patient or representative has signed informed consent.