NCT06857851Recruiting
Optimizing Deep Brain Stimulation to Improve Visuomotor Function in Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 7 Jul 2026
Brief summary (registry, in English)
Inability to align and refocus the eyes on the objects at different depths, i.e., vergence impairment and strabismus, frequently affects the quality of life in patients with Parkinson's disease. The investigators study aims to understand the location-specific effects of subthalamic region deep brain stimulation on vergence and strabismus by integrating the patient-specific deep brain stimulation models and high-resolution eye-tracking measures. The knowledge gained will allow the investigators to find the most beneficial stimulation location and parameters for improving binocular coordination, strabismus, and vergence while preserving the ability to treat motor symptoms in Parkinson's disease.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 80 (estimated)
- First submitted
- 19 Feb 2025
- Start date
- 1 Feb 2026
- Primary completion date
- 30 Sept 2029
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Parkinson disease
- NCT number
- NCT06857851
What you commit to
- Study type: Observational
- Planned participants: 80
- From 1 Feb 2026 to the primary completion date, 30 Sept 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous surgical therapy for Parkinson's disease (other than DBS)
Other illness
- Dementia
Other
- Clinically significant untreated depression or anxiety
- Clinical features suggestive of atypical parkinsonism
Who the study is looking for
- Parkinson's disease with bilateral STN DBS
- Availability of pre-operative MR images (with a T1-weighted, gradient-echo sequence) and ability to get post-operative MRI or CT scans
- Hoehn and Yahr stage 2-4 when off medication, and a stable antiparkinsonian medication regimen and DBS parameter settings
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Louis Stokes VA Medical Center, Cleveland, OH Coordinator of this site? Confirm its status | Cleveland | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.