Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight

Prior treatment

• Self-reported change in body weight \> 5 kg within 90 days before screening.
• History of chronic pancreatitis or history of acute pancreatitis within 180 days before screening.

Other illness

• Type 1 diabetes mellitus.
• Obesity induced by other endocrinologic disorders.
• Family (first-degree relative\[s\]) or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2.
• History of unstable major depressive disorder (MDD) or other severe psychiatric disorder within 2 years before screening.
• Lifetime history of suicide attempt.

Other

• Proliferative diabetic retinopathy OR diabetic macular edema OR non-proliferative diabetic retinopathy that requires acute treatment.

• Age ≥ 18 years.
• Body mass index ≥ 27 kg/m\^2.
• History of at least 1 self-reported unsuccessful attempt at weight loss by diet and exercise.
• Diagnosis of T2DM.