NCT06859151Not yet recruiting
DNA Methylation and the Increased Risk of Cervical Cancer Development
The Role of the Genital Tract Microbiota in Cervical Epithelial Cell DNA Methylation and the Increased Risk of Cervical Cancer Development
Source: ClinicalTrials.gov · Last updated 5 Mar 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This study aims to investigate the correlation between reproductive tract microbiota and DNA methylation in cervical epithelial cells, as well as its impact on the development of cervical cancer, through a paired case-control clinical study
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 2000 (estimated)
- First submitted
- 27 Feb 2025
- Start date
- 20 Mar 2025
- Primary completion date
- 30 Dec 2025
- Lead sponsor
- Zhujiang Hospital
- Diseases
- Cervical cancer, Childhood cancers
- NCT number
- NCT06859151
What you commit to
- Study type: Observational
- Planned participants: 2000
- From 20 Mar 2025 to the primary completion date, 30 Dec 2025
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Those who have had organ transplants or are currently using immunosuppressive agents
- Use of vaginal probiotics within one month before sample collection
- Use of vaginal antibiotics or antifungal treatments within one month before sample collection
Other illness
- Patients with immunological disorders or severe autoimmune diseases, such as AIDS, SLE
- History of surgery related to cervical intraepithelial neoplasia (CIN), including but not limited to conization of the cervix, LEEP procedures, etc.
Other
- Pregnant or breastfeeding
- Use of vaginal douching within 48 hours before sample collection
- Blood samples (avoid sampling during menstruation), insufficient remaining sample volume to support subsequent analysis needs, and samples not stored as required.
Who the study is looking for
- Aged 18-50 years old, with a history of sexual activity
- HPV and TCT tests are performed concurrently in the gynecology clinic
- Those with abnormal HPV and TCT test results undergo tissue pathological testing
Age in the registry: 15 years to 50 years · Sex: Female · Accepts healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.