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NCT06859268Active, not recruitingPhase 3

A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity

A Phase 3b, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Retatrutide Treatment in the Maintenance of Weight Reduction in Individuals With Obesity

Source: ClinicalTrials.gov · Last updated 3 Mar 2026

Brief summary (registry, in English)

This is a study of retatrutide in participants with obesity. The main purpose is to learn more about how retatrutide maintains body weight loss. The study will have two treatment phases: an 80 week lead-in phase in which all participants will take retatrutide dose 1 and a 36 week randomized, double-blinded phase in which participants will either take retatrutide dose 1, retatrutide dose 2, or switch to placebo. Participation in the study will last around 125 weeks.

Status (registry)
Active, not recruiting
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
643 (estimated)
First submitted
28 Feb 2025
Start date
5 Mar 2025
Primary completion date
Apr 2028
Lead sponsor
Eli Lilly and Company
Diseases
Obesity
NCT number
NCT06859268

What you commit to

  • Study type: Interventional · Phase 3
  • Planned participants: 643
  • From 5 Mar 2025 to the primary completion date, Apr 2028
  • 53 sites in 3 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Have a self-reported change in body weight \>5 kilograms (kg) (11 pounds) within 90 days before screening
  • Have a prior or planned surgical treatment for obesity
  • Have a prior or planned endoscopic procedure and/or device-based therapy for obesity
  • Have had within the past 90 days before screening:
    • acute myocardial infarction
    • cerebrovascular accident (stroke)
    • hospitalization for unstable angina, or
    • hospitalization due to congestive heart failure
  • Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening

Other illness

  • Have Type 1 Diabetes, Type 2 Diabetes, or any other type of diabetes
  • Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
  • Have New York Heart Association Functional Classification Class IV congestive heart failure
  • Have a history of chronic or acute pancreatitis

Who the study is looking for

  • Have obesity and a history of at least one self-reported unsuccessful dietary effort to reduce body weight

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (53)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
Aggarwal and Associates Limited
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BramptonCanadaUnknown status
Circulate Cardiac & Vascular Centre
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BurlingtonCanadaUnknown status
Med Trust Research
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CourticeCanadaUnknown status
Winterberry Research Inc.
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HamiltonCanadaUnknown status
Centre de Medecine Metabolique de Lanaudiere (CMML)
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TerrebonneCanadaUnknown status
Care Access - Thunder Bay - Barton Street
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Thunder BayCanadaUnknown status
Maple Leaf Research
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TorontoCanadaUnknown status
C.I.C. Mauricie inc.
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Trois-RivièresCanadaUnknown status
FutureMeds - Birmingham
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BirminghamUnited KingdomUnknown status
Oakenhurst Medical Practice
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BlackburnUnited KingdomUnknown status
Layton Medical Centre
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BlackpoolUnited KingdomUnknown status
Bradford on Avon Health Centre
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Bradford on AvonUnited KingdomUnknown status
FutureMeds - Liverpool
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BromboroughUnited KingdomUnknown status
Cheadle Community Hospital
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CheadleUnited KingdomUnknown status
HMC Health Group - Meadows Centre for Health
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HounslowUnited KingdomUnknown status
St Bartholomew's Medical Centre
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OxfordUnited KingdomUnknown status
Atlantic Medical
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PenzanceUnited KingdomUnknown status
The Adam Practice
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PooleUnited KingdomUnknown status
Woodstock Bower Surgery
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RotherhamUnited KingdomUnknown status
Rame Group Practice
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TorpointUnited KingdomUnknown status
Dent Neurosciences Research Center, Inc
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AmherstUnited StatesUnknown status
University of Colorado Anschutz Medical Campus
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AuroraUnited StatesUnknown status
Pennington Biomedical Research Center
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Baton RougeUnited StatesUnknown status
Northwest Clinical Research Center
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BellevueUnited StatesUnknown status
Massachusetts General Hospital
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BostonUnited StatesUnknown status
ALL Medical Research, LLC
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Cooper CityUnited StatesUnknown status
Florida International Medical Research
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Coral GablesUnited StatesUnknown status
Altoona Center For Clinical Research
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DuncansvilleUnited StatesUnknown status
CMR of Greater New Haven, LLC
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HamdenUnited StatesUnknown status
Pacific Diabetes & Endocrine Center
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HonoluluUnited StatesUnknown status
Care Access - Houston
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HoustonUnited StatesUnknown status
Alliance for Multispecialty Research, LLC
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Kansas CityUnited StatesUnknown status
Alliance for Multispecialty Research, LLC
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KnoxvilleUnited StatesUnknown status
Care Access - Lake Charles (Bayou Pines)
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Lake CharlesUnited StatesUnknown status
Vector Clinical Trials
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Las VegasUnited StatesUnknown status
Alliance for Multispecialty Research, LLC
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LexingtonUnited StatesUnknown status
L-MARC Research Center
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LouisvilleUnited StatesUnknown status
Kubost Clinical Research - Marietta
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MariettaUnited StatesUnknown status
Southern Endocrinology Associates
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MesquiteUnited StatesUnknown status
Tekton Research, LLC.
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MooreUnited StatesUnknown status
Carteret Medical Group
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Morehead CityUnited StatesUnknown status
Alliance for Multispecialty Research, LLC
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Oak BrookUnited StatesUnknown status
Renstar Medical Research
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OcalaUnited StatesUnknown status
Charter Research - Winter Park
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OrlandoUnited StatesUnknown status
Care Access - Raleigh
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RaleighUnited StatesUnknown status
Care Access - Rapid City
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Rapid CityUnited StatesUnknown status
National Clinical Research, Inc
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RichmondUnited StatesUnknown status
Sleep Therapy Research Center
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San AntonioUnited StatesUnknown status
Southern California Clinical Research
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Santa AnaUnited StatesUnknown status
Springfield Clinic Main Campus
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SpringfieldUnited StatesUnknown status
Central Washington Health Services Association d/b/a Confluence Health
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WenatcheeUnited StatesUnknown status
Metabolic Research Institute, Inc
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West Palm BeachUnited StatesUnknown status
North Georgia Clinical Research
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WoodstockUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.