NCT06859268Active, not recruitingPhase 3
A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity
A Phase 3b, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Retatrutide Treatment in the Maintenance of Weight Reduction in Individuals With Obesity
Source: ClinicalTrials.gov · Last updated 3 Mar 2026
Brief summary (registry, in English)
This is a study of retatrutide in participants with obesity. The main purpose is to learn more about how retatrutide maintains body weight loss. The study will have two treatment phases: an 80 week lead-in phase in which all participants will take retatrutide dose 1 and a 36 week randomized, double-blinded phase in which participants will either take retatrutide dose 1, retatrutide dose 2, or switch to placebo. Participation in the study will last around 125 weeks.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 643 (estimated)
- First submitted
- 28 Feb 2025
- Start date
- 5 Mar 2025
- Primary completion date
- Apr 2028
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Obesity
- NCT number
- NCT06859268
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 643
- From 5 Mar 2025 to the primary completion date, Apr 2028
- 53 sites in 3 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have a self-reported change in body weight \>5 kilograms (kg) (11 pounds) within 90 days before screening
- Have a prior or planned surgical treatment for obesity
- Have a prior or planned endoscopic procedure and/or device-based therapy for obesity
- Have had within the past 90 days before screening:
- acute myocardial infarction
- cerebrovascular accident (stroke)
- hospitalization for unstable angina, or
- hospitalization due to congestive heart failure
- Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening
Other illness
- Have Type 1 Diabetes, Type 2 Diabetes, or any other type of diabetes
- Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
- Have New York Heart Association Functional Classification Class IV congestive heart failure
- Have a history of chronic or acute pancreatitis
Who the study is looking for
- Have obesity and a history of at least one self-reported unsuccessful dietary effort to reduce body weight
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (53)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Aggarwal and Associates Limited Coordinator of this site? Confirm its status | Brampton | Canada | Unknown status |
| Circulate Cardiac & Vascular Centre Coordinator of this site? Confirm its status | Burlington | Canada | Unknown status |
| Med Trust Research Coordinator of this site? Confirm its status | Courtice | Canada | Unknown status |
| Winterberry Research Inc. Coordinator of this site? Confirm its status | Hamilton | Canada | Unknown status |
| Centre de Medecine Metabolique de Lanaudiere (CMML) Coordinator of this site? Confirm its status | Terrebonne | Canada | Unknown status |
| Care Access - Thunder Bay - Barton Street Coordinator of this site? Confirm its status | Thunder Bay | Canada | Unknown status |
| Maple Leaf Research Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| C.I.C. Mauricie inc. Coordinator of this site? Confirm its status | Trois-Rivières | Canada | Unknown status |
| FutureMeds - Birmingham Coordinator of this site? Confirm its status | Birmingham | United Kingdom | Unknown status |
| Oakenhurst Medical Practice Coordinator of this site? Confirm its status | Blackburn | United Kingdom | Unknown status |
| Layton Medical Centre Coordinator of this site? Confirm its status | Blackpool | United Kingdom | Unknown status |
| Bradford on Avon Health Centre Coordinator of this site? Confirm its status | Bradford on Avon | United Kingdom | Unknown status |
| FutureMeds - Liverpool Coordinator of this site? Confirm its status | Bromborough | United Kingdom | Unknown status |
| Cheadle Community Hospital Coordinator of this site? Confirm its status | Cheadle | United Kingdom | Unknown status |
| HMC Health Group - Meadows Centre for Health Coordinator of this site? Confirm its status | Hounslow | United Kingdom | Unknown status |
| St Bartholomew's Medical Centre Coordinator of this site? Confirm its status | Oxford | United Kingdom | Unknown status |
| Atlantic Medical Coordinator of this site? Confirm its status | Penzance | United Kingdom | Unknown status |
| The Adam Practice Coordinator of this site? Confirm its status | Poole | United Kingdom | Unknown status |
| Woodstock Bower Surgery Coordinator of this site? Confirm its status | Rotherham | United Kingdom | Unknown status |
| Rame Group Practice Coordinator of this site? Confirm its status | Torpoint | United Kingdom | Unknown status |
| Dent Neurosciences Research Center, Inc Coordinator of this site? Confirm its status | Amherst | United States | Unknown status |
| University of Colorado Anschutz Medical Campus Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Pennington Biomedical Research Center Coordinator of this site? Confirm its status | Baton Rouge | United States | Unknown status |
| Northwest Clinical Research Center Coordinator of this site? Confirm its status | Bellevue | United States | Unknown status |
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| ALL Medical Research, LLC Coordinator of this site? Confirm its status | Cooper City | United States | Unknown status |
| Florida International Medical Research Coordinator of this site? Confirm its status | Coral Gables | United States | Unknown status |
| Altoona Center For Clinical Research Coordinator of this site? Confirm its status | Duncansville | United States | Unknown status |
| CMR of Greater New Haven, LLC Coordinator of this site? Confirm its status | Hamden | United States | Unknown status |
| Pacific Diabetes & Endocrine Center Coordinator of this site? Confirm its status | Honolulu | United States | Unknown status |
| Care Access - Houston Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Alliance for Multispecialty Research, LLC Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Alliance for Multispecialty Research, LLC Coordinator of this site? Confirm its status | Knoxville | United States | Unknown status |
| Care Access - Lake Charles (Bayou Pines) Coordinator of this site? Confirm its status | Lake Charles | United States | Unknown status |
| Vector Clinical Trials Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Alliance for Multispecialty Research, LLC Coordinator of this site? Confirm its status | Lexington | United States | Unknown status |
| L-MARC Research Center Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Kubost Clinical Research - Marietta Coordinator of this site? Confirm its status | Marietta | United States | Unknown status |
| Southern Endocrinology Associates Coordinator of this site? Confirm its status | Mesquite | United States | Unknown status |
| Tekton Research, LLC. Coordinator of this site? Confirm its status | Moore | United States | Unknown status |
| Carteret Medical Group Coordinator of this site? Confirm its status | Morehead City | United States | Unknown status |
| Alliance for Multispecialty Research, LLC Coordinator of this site? Confirm its status | Oak Brook | United States | Unknown status |
| Renstar Medical Research Coordinator of this site? Confirm its status | Ocala | United States | Unknown status |
| Charter Research - Winter Park Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Care Access - Raleigh Coordinator of this site? Confirm its status | Raleigh | United States | Unknown status |
| Care Access - Rapid City Coordinator of this site? Confirm its status | Rapid City | United States | Unknown status |
| National Clinical Research, Inc Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| Sleep Therapy Research Center Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Southern California Clinical Research Coordinator of this site? Confirm its status | Santa Ana | United States | Unknown status |
| Springfield Clinic Main Campus Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Central Washington Health Services Association d/b/a Confluence Health Coordinator of this site? Confirm its status | Wenatchee | United States | Unknown status |
| Metabolic Research Institute, Inc Coordinator of this site? Confirm its status | West Palm Beach | United States | Unknown status |
| North Georgia Clinical Research Coordinator of this site? Confirm its status | Woodstock | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.