NCT06861790Recruiting
WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function)
Obesity and Type 2 Diabetes: Bariatric Surgery Effects on Brain Function -Part 2 (WISE-2B Brain Study)
Source: ClinicalTrials.gov · Last updated 10 Feb 2026
Brief summary (registry, in English)
The goal of the study to understand the effects of weight loss and improvements in diabetes following bariatric surgery on brain function and thinking. This study will also examine whether non-invasive transcutaneous vagal nerve stimulation (tVNS) intervention initiated 30 days post-surgery improves brain function and thinking. The study does NOT cover any costs associated with bariatric surgery.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 7 Feb 2025
- Start date
- 10 Nov 2025
- Primary completion date
- Dec 2027
- Lead sponsor
- University of Florida
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT06861790
What you commit to
- Study type: Interventional
- Planned participants: 120
- From 10 Nov 2025 to the primary completion date, Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior or current neurological disorder
- MRI contraindications (claustrophobia, metal implants, waist/torso circumference)
Other illness
- Major psychiatric disturbance
- Unstable medical conditions (cancer)
Who the study is looking for
- Between age: 20-75 yrs, English speaking, Physically mobile
- Body Mass Index (BMI) \>35 kg before surgery
- Compatible of MRI Scanning
- Willing to give a small blood sample
- Capable of providing informed consent
Age in the registry: 20 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Florida - College of Public Health and Health Professions Coordinator of this site? Confirm its status | Gainesville | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.