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NCT06863233CompletedPhase 1

A Study of CD8+ T Cell Imaging During Treatment in People With Non-Small Cell Lung Cancer

Assessment of Patients Immune Response After Treatment With Engineered Tumor Infiltrating Lymphocyte Therapy Incorporating CD8 PET Imaging

Source: ClinicalTrials.gov · Last updated 26 Aug 2026

Brief summary (registry, in English)

The purpose of this study to learn whether PET/CT (positron emission tomography/computed tomography) scans using an imaging agent (radiotracer) called zirconium Zr 89 crefmirlimab berdoxam is a safe and effective way to identify CD8+ T cells

Status (registry)
Completed
Phase (registry)
Phase 1
Study type
Interventional
Enrollment
4 (actual)
First submitted
3 Mar 2025
Start date
3 Mar 2025
Primary completion date
24 Aug 2026
Lead sponsor
Memorial Sloan Kettering Cancer Center
Diseases
Lung cancer
NCT number
NCT06863233

What you commit to

  • Study type: Interventional · Phase 1
  • Participants enrolled: 4
  • From 3 Mar 2025 to the primary completion date, 24 Aug 2026
  • 7 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Patients with a history of splenectomy or significant splenic dysfunction (e.g., as evidenced by splenomegaly or a history of recurrent infections due to impaired immune function)

Other

  • Pregnant or breastfeeding women

Who the study is looking for

  • Patient must be 18 years of age or older at the time of signing the informed consent.
  • Patient has a histologically confirmed diagnosis of metastatic non-small cell lung cancer
  • Patient is enrolled in the engineered TIL cell therapy protocol OBX115-23-01, but has not received the treatment yet.
  • Men and women of child-producing potential, use of effective double barrier contraceptive methods during the study, up to 30 days after the last administration of the investigational product.
  • Patient or legally authorized representative provided signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.
  • Patient or legally authorized representative provided written authorization for use and disclosure of protected health information.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (7)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Memorial Sloan Kettering at Basking Ridge (Consent Only)
Coordinator of this site? Confirm its status
Basking RidgeUnited StatesUnknown status
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Consent only)
Coordinator of this site? Confirm its status
CommackUnited StatesUnknown status
Memorial Sloan Kettering Westchester (Consent only)
Coordinator of this site? Confirm its status
HarrisonUnited StatesUnknown status
Memorial Sloan Kettering Monmouth (Consent Only)
Coordinator of this site? Confirm its status
MiddletownUnited StatesUnknown status
Memorial Sloan Kettering Bergen (Consent Only)
Coordinator of this site? Confirm its status
MontvaleUnited StatesUnknown status
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
Coordinator of this site? Confirm its status
New YorkUnited StatesUnknown status
Memorial Sloan Kettering Cancer Center @ Nassau (Consent only)
Coordinator of this site? Confirm its status
UniondaleUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.