NCT06864104CompletedPhase 2
A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)
A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Monthly Subcutaneous Administration of Tonlamarsen in Participants With Uncontrolled Hypertension (KARDINAL)
Source: ClinicalTrials.gov · Last updated 31 Mar 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the blood pressure (BP)-lowering efficacy of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 206 (actual)
- First submitted
- 12 Feb 2025
- Start date
- 10 Apr 2025
- Primary completion date
- 12 Jan 2026
- Lead sponsor
- Kardigan, Inc.
- Diseases
- High blood pressure
- NCT number
- NCT06864104
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 206
- From 10 Apr 2025 to the primary completion date, 12 Jan 2026
- 39 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Has known history of secondary hypertension
- Has documented history of poor adherence to antihypertensive medication
- Has unstable/underlying known cardiovascular disease
Other
- Has abnormal thyroid function with clinical significance
Who the study is looking for
- Age 18 to 80, body weight ≥ 50 kg
- Has uncontrolled hypertension while receiving between 2 and 5 antihypertensive medications prescribed for hypertension
- Has mean office seated systolic blood pressure \> 135 to ≤ 170 mmHg
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (39)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Pinnacle Research Group Coordinator of this site? Confirm its status | Anniston | United States | Unknown status |
| Agile Clinical Research Trials, LLC Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Central Texas Clinical Research Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Achieve Clinical Research, LLC Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| Eagle Clinical Research Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| North Coast Cardiology Coordinator of this site? Confirm its status | Encinitas | United States | Unknown status |
| Advanced Medical Trials, LLC Coordinator of this site? Confirm its status | Georgetown | United States | Unknown status |
| Clinical Investigation Specialists, Inc. Coordinator of this site? Confirm its status | Gurnee | United States | Unknown status |
| Homestead Associates in Research Inc Coordinator of this site? Confirm its status | Homestead | United States | Unknown status |
| Juno Research, LLC Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Jacksonville Center for Clinical Research Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Holston Medical Group. Coordinator of this site? Confirm its status | Kingsport | United States | Unknown status |
| Orange County Research Center Coordinator of this site? Confirm its status | Lake Forest | United States | Unknown status |
| Radiance Clinical Research Coordinator of this site? Confirm its status | Lampasas | United States | Unknown status |
| IMA Clinical Research Coordinator of this site? Confirm its status | Lenoir | United States | Unknown status |
| Clinical Trials Research Coordinator of this site? Confirm its status | Lincoln | United States | Unknown status |
| Cardiology and Medicine Clinic Coordinator of this site? Confirm its status | Little Rock | United States | Unknown status |
| American Institute of Research Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Manassas Clinical Research Center Coordinator of this site? Confirm its status | Manassas | United States | Unknown status |
| Tandem Clinical Research GI, LLC Coordinator of this site? Confirm its status | Marrero | United States | Unknown status |
| ActivMed Practices & Research, LLC Coordinator of this site? Confirm its status | Methuen | United States | Unknown status |
| Synergy Groups Medical LLC Coordinator of this site? Confirm its status | Missouri City | United States | Unknown status |
| Clinical Trials of South Carolina Coordinator of this site? Confirm its status | Moncks Corner | United States | Unknown status |
| IMA Clinical Research Coordinator of this site? Confirm its status | Monroe | United States | Unknown status |
| Koch Family Medicine Clinical Research Coordinator of this site? Confirm its status | Morton | United States | Unknown status |
| DelRicht Clinical Research - New Orleans Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| Suncoast Clinical Research, Inc. Coordinator of this site? Confirm its status | New Port Richey | United States | Unknown status |
| York Clinical Research LLC Coordinator of this site? Confirm its status | Norfolk | United States | Unknown status |
| North Hills Medical Research Coordinator of this site? Confirm its status | North Richland Hills | United States | Unknown status |
| Olive Branch Family Medical Center Coordinator of this site? Confirm its status | Olive Branch | United States | Unknown status |
| Elite Clinical Studies Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Progressive Medical Research Coordinator of this site? Confirm its status | Port Orange | United States | Unknown status |
| Health Concepts Coordinator of this site? Confirm its status | Rapid City | United States | Unknown status |
| Sun Research Institute Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Velocity Clinical Reseach Coordinator of this site? Confirm its status | Savannah | United States | Unknown status |
| Richmond University Medical Center Coordinator of this site? Confirm its status | Staten Island | United States | Unknown status |
| CHEAR Center LLC Coordinator of this site? Confirm its status | The Bronx | United States | Unknown status |
| Oakland Medical Research Center Coordinator of this site? Confirm its status | Troy | United States | Unknown status |
| Del Sol Research Management, LLC Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
Related publications
- Efficacy of Tonlamarsen in Patients With Uncontrolled Hypertension: The KARDINAL Phase 2 Randomized Clinical Trial.J Am Coll Cardiol · 2026 · PMID 41949512
This page is information, not medical advice. Discuss any trial with your doctor.